The potential of stem cells as an in vitro source of red blood cells for transfusion Journal Article
| Authors: | Migliaccio, A. R.; Whitsett, C.; Papayannopoulou, T.; Sadelain, M. |
| Article Title: | The potential of stem cells as an in vitro source of red blood cells for transfusion |
| Abstract: | Recent advances have increased excitement about the potential for therapeutic production of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers required for transfusion remains a significant challenge. In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena. © 2012 Elsevier Inc. |
| Keywords: | review; antigen expression; homologous recombination; stem cell transplantation; in vitro study; drug development; myelodysplastic syndrome; blood transfusion; hemolytic anemia; patient compliance; erythrocyte; drug delivery system; blood clotting factor 9; hemophilia; cell membrane potential |
| Journal Title: | Cell Stem Cell |
| Volume: | 10 |
| Issue: | 2 |
| ISSN: | 1934-5909 |
| Publisher: | Cell Press |
| Date Published: | 2012-02-01 |
| Start Page: | 115 |
| End Page: | 119 |
| Language: | English |
| DOI: | 10.1016/j.stem.2012.01.001 |
| PROVIDER: | scopus |
| PUBMED: | 22305561 |
| PMCID: | PMC3676433 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2012" - "Source: Scopus" |
