Cervical metastasis of germ cell tumors: Evaluation, management, complications, and outcomes Journal Article

  

Authors:	Mehra, S.; Liu, J.; Gupta, A.; Sheinfeld, J.; Kraus, D.
Article Title:	Cervical metastasis of germ cell tumors: Evaluation, management, complications, and outcomes
Abstract:	Objectives/Hypothesis: Head and neck surgeons can be involved in the management of germ cell tumor (GCT) metastatic to the neck from initial diagnosis through postchemotherapy management of residual neck masses. This article reports on 34 consecutive patients with GCT metastatic to the neck. Study Design: Retrospective chart review. Methods: A single-institution retrospective chart review of 34 consecutive patients with GCT metastatic to the neck who underwent postchemotherapy neck surgery between 1991 and 2009 was performed. Results: Seventy-four percent of patients had a neck mass at initial diagnosis, with 50% of patients having a neck mass as the presenting symptom leading to a diagnosis of GCT. Of the 37 neck procedures, positive nodes were found in 22. No significant relationship between preoperative tumor markers and neck pathology (P =.35) was identified. No patients had neck recurrence. No patients had permanent nerve injury or chyle leak. As a secondary end point, survival analysis related to cervical pathology showed that viable tumor in the neck predicted disease-specific survival (P =.01). Five- and 10-year disease-specific survival was 82.3% (median, 52-month follow-up). Conclusions: Operative management for patients with metastatic GCT to the neck can achieve long-term durable cervical control with limited complications. © 2011 The American Laryngological.
Keywords:	adult; cancer survival; clinical article; treatment outcome; disease-free survival; middle aged; survival rate; retrospective studies; young adult; review; cancer recurrence; neck dissection; united states; cancer patient; combined modality therapy; follow-up studies; etoposide; retrospective study; tumor marker; symptom; preoperative period; evaluation; head and neck neoplasms; neoplasm metastasis; testicular neoplasms; lactate dehydrogenase; testicular cancer; neoplasms, germ cell and embryonal; germ cell tumor; disease specific survival; alpha fetoprotein; chorionic gonadotropin; neck metastasis; cervical metastases; level of evidence: 2b; neck mass
Journal Title:	Laryngoscope
Volume:	122
Issue:	2
ISSN:	0023-852X
Publisher:	Wiley Blackwell
Date Published:	2012-02-01
Start Page:	286
End Page:	290
Language:	English
DOI:	10.1002/lary.22422
PROVIDER:	scopus
PUBMED:	22252920
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84862786870&partnerID=40&md5=dfe274d20ea2f9398b674eff6067aed3
Notes:	--- - "Export Date: 1 March 2012" - "CODEN: LARYA" - "Source: Scopus"

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