| Abstract: |
Purpose of Review: This review is to provide an update on the current status of partial breast irradiation (PBI) for women presenting with early-stage breast cancer, as an alternate radiation technique to fractionated, whole breast radiation, following conservation surgery. As more women are asking for and receiving this treatment, both on and off protocols, understanding recent additions to the literature is important to physicians caring for this patient population. Recent Findings: Newly published retrospective studies, with follow-up times out to 10 years and the status of both recently completed and still open large prospective phase III trials will be covered, with emphasis on unexpected side effects reported, and some hypothesis-generating radiobiology observations. A recent consensus treatment guideline for PBI use is also discussed. Summary: Selected retrospective studies continue to report outcomes matching those achieved with whole breast radiation; however, results from large prospective randomized trials comparing PBI to whole breast radiation have been reported only with short follow-up times, or in two studies, are still pending. A recent consensus guideline is useful at present in selecting patients for discussion of this treatment. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Keywords: |
aged; middle aged; review; patient selection; cancer radiotherapy; follow up; treatment indication; neoplasm recurrence, local; breast cancer; breast; radiotherapy dosage; randomized controlled trials as topic; practice guideline; radiation injury; breast neoplasms; retrospective study; early cancer; consensus development; radiotherapy planning, computer-assisted; mastectomy, segmental; carcinoma, ductal, breast; carcinoma, lobular; radiobiology; phase 3 clinical trial (topic); early-stage breast cancer; breast conservation surgery and radiation; partial breast radiation
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