Immunohistochemical expression of estrogen and progesterone receptors and outcomes in patients with newly diagnosed uterine leiomyosarcoma Journal Article

Authors: Leitao, M. M. Jr; Hensley, M. L.; Barakat, R. R.; Aghajanian, C.; Gardner, G. J.; Jewell, E. L.; O'cearbhaill, R.; Soslow, R. A.
Article Title: Immunohistochemical expression of estrogen and progesterone receptors and outcomes in patients with newly diagnosed uterine leiomyosarcoma
Abstract: Objective: We assessed the IHC expression of ER and PR and their prognostic significance in uterine leiomyosarcoma (LMS). Methods: We identified 43 "high-grade" uterine LMS cases from 7/82-7/07 for whom ER/PR IHC analysis was performed at initial diagnosis at our institution. Results: Disease was confined to the uterine body in 20/43 (47%). Eighteen (42%) of 43 were ER(+); 17/42 (41%) were PR(+). At last follow-up, 33 (77%) had recurred or progressed, and 23 (54%) had died. PR expression was associated with improved progression-free survival (PFS; P = 0.002) and overall survival (OS; P = 0.03) overall; ER expression was not. After adjusting for stage, ER expression was associated with PFS (P = 0.01), not OS (P = 0.3), and PR expression maintained a significant association with PFS (P = 0.002) and approached a significant association with OS (P = 0.05). Neither ER nor PR expression was associated with outcome in cases with disease outside the uterine body. In cases with confined disease, median PFS for ER(+) or PR(+) cases was not reached compared to 16.9 months for ER(-) cases (95% CI: 8.1-25.7; P = 0.03) and 13.5 months for PR(-) cases (95% CI: 5.9-21.1; P = 0.001). Only 1/10 PR(+) cases recurred and died; 9/10 PR(-) cases recurred, and 5 died. Two of 9 ER(+) cases recurred and died; 8/11 ER(-) cases recurred, and 4 died. Conclusion: ER/PR expression is associated with survival outcomes in patients with high-grade uterine LMS confined to the uterine body. PR expression seems capable of identifying cases confined to the uterine body, which have better outcomes. © 2011 Elsevier Inc. All rights reserved.
Keywords: immunohistochemistry; adult; cancer survival; clinical article; human tissue; protein expression; aged; cancer localization; cancer recurrence; cancer growth; cancer patient; outcome assessment; follow up; cancer grading; disease association; cancer mortality; outcome; leiomyosarcoma; estrogen receptor; progesterone receptor; uterine leiomyosarcoma; uterus sarcoma; cancer prognosis
Journal Title: Gynecologic Oncology
Volume: 124
Issue: 3
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2012-03-01
Start Page: 558
End Page: 562
Language: English
DOI: 10.1016/j.ygyno.2011.11.009
PROVIDER: scopus
PUBMED: 22085894
Notes: --- - "Export Date: 1 March 2012" - "CODEN: GYNOA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Ginger J Gardner
    165 Gardner
  2. Elizabeth Jewell
    66 Jewell
  3. Richard R Barakat
    629 Barakat
  4. Mario Leitao
    367 Leitao
  5. Martee L Hensley
    238 Hensley
  6. Robert Soslow
    715 Soslow