Immunohistochemical expression of estrogen and progesterone receptors and outcomes in patients with newly diagnosed uterine leiomyosarcoma Journal Article

  

Authors:	Leitao, M. M. Jr; Hensley, M. L.; Barakat, R. R.; Aghajanian, C.; Gardner, G. J.; Jewell, E. L.; O'cearbhaill, R.; Soslow, R. A.
Article Title:	Immunohistochemical expression of estrogen and progesterone receptors and outcomes in patients with newly diagnosed uterine leiomyosarcoma
Abstract:	Objective: We assessed the IHC expression of ER and PR and their prognostic significance in uterine leiomyosarcoma (LMS). Methods: We identified 43 "high-grade" uterine LMS cases from 7/82-7/07 for whom ER/PR IHC analysis was performed at initial diagnosis at our institution. Results: Disease was confined to the uterine body in 20/43 (47%). Eighteen (42%) of 43 were ER(+); 17/42 (41%) were PR(+). At last follow-up, 33 (77%) had recurred or progressed, and 23 (54%) had died. PR expression was associated with improved progression-free survival (PFS; P = 0.002) and overall survival (OS; P = 0.03) overall; ER expression was not. After adjusting for stage, ER expression was associated with PFS (P = 0.01), not OS (P = 0.3), and PR expression maintained a significant association with PFS (P = 0.002) and approached a significant association with OS (P = 0.05). Neither ER nor PR expression was associated with outcome in cases with disease outside the uterine body. In cases with confined disease, median PFS for ER(+) or PR(+) cases was not reached compared to 16.9 months for ER(-) cases (95% CI: 8.1-25.7; P = 0.03) and 13.5 months for PR(-) cases (95% CI: 5.9-21.1; P = 0.001). Only 1/10 PR(+) cases recurred and died; 9/10 PR(-) cases recurred, and 5 died. Two of 9 ER(+) cases recurred and died; 8/11 ER(-) cases recurred, and 4 died. Conclusion: ER/PR expression is associated with survival outcomes in patients with high-grade uterine LMS confined to the uterine body. PR expression seems capable of identifying cases confined to the uterine body, which have better outcomes. © 2011 Elsevier Inc. All rights reserved.
Keywords:	immunohistochemistry; adult; cancer survival; clinical article; human tissue; protein expression; aged; cancer localization; cancer recurrence; cancer growth; cancer patient; outcome assessment; follow up; cancer grading; disease association; cancer mortality; outcome; leiomyosarcoma; estrogen receptor; progesterone receptor; uterine leiomyosarcoma; uterus sarcoma; cancer prognosis
Journal Title:	Gynecologic Oncology
Volume:	124
Issue:	3
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2012-03-01
Start Page:	558
End Page:	562
Language:	English
DOI:	10.1016/j.ygyno.2011.11.009
PROVIDER:	scopus
PUBMED:	22085894
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84856752432&partnerID=40&md5=e07059901debc7c4c563b7333c4fb13c
Notes:	--- - "Export Date: 1 March 2012" - "CODEN: GYNOA" - "Source: Scopus"