Intravesical bacillus Calmette-Guérin outcomes in patients with bladder cancer and asymptomatic bacteriuria Journal Article
| Author: | Herr, H. W. |
| Article Title: | Intravesical bacillus Calmette-Guérin outcomes in patients with bladder cancer and asymptomatic bacteriuria |
| Abstract: | The outcome of intravesical bacillus Calmette-Guérin therapy was studied in patients with asymptomatic bacteriuria. A total of 243 patients with high risk, nonmuscle invasive bladder cancer received induction intravesical bacillus Calmette-Guérin therapy. Before starting bacillus Calmette-Guérin they submitted voided urine samples for culture and were treated with bacillus Calmette-Guérin regardless of culture results without antibiotics. Patients were followed every 3 months for tumor recurrence or progression up to 2 years. Of the 243 patients 61 (25%) had significant bacteriuria (greater than 10 4 or greater than 10 5 cfu/ml single organism). Febrile urinary tract infection developed in 1 patient (1.6%) and 2 overall (0.8%) after completing induction bacillus Calmette-Guérin therapy. No patients were admitted to the hospital for bacillus Calmette-Guérin or bacterial sepsis. The 2-year recurrence-free survival rate was 71% vs 73% in uninfected patients (p = 0.73). These data suggest that intravesical bacillus Calmette-Guérin is safe in patients who have asymptomatic bacteriuria and the 2-year disease-free intervals are similar to those of uninfected patients. Such strategy facilitates the timely administration of bacillus Calmette-Guérin therapy and avoids the overuse of antibiotics. © 2012 American Urological Association Education and Research, Inc. |
| Keywords: | adult; controlled study; treatment outcome; aged; major clinical study; cancer recurrence; cancer growth; cancer risk; follow up; bcg vaccine; bladder cancer; urinary bladder neoplasms; high risk patient; fever; cancer invasion; urinary tract infection; mycobacterium bovis; bacteriuria; urinalysis; bacterium culture; recurrence free survival; colony forming unit; asymptomatic bacteriuria; nonmuscle invasive bladder cancer; febrile urinary tract infection |
| Journal Title: | Journal of Urology |
| Volume: | 187 |
| Issue: | 2 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2012-02-01 |
| Start Page: | 435 |
| End Page: | 437 |
| Language: | English |
| DOI: | 10.1016/j.juro.2011.10.032 |
| PROVIDER: | scopus |
| PUBMED: | 22177154 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2012" - "CODEN: JOURA" - "Source: Scopus" |
