Autophagy and ammonia Journal Article
| Authors: | Cheong, H.; Lindsten, T.; Thompson, C. B. |
| Article Title: | Autophagy and ammonia |
| Abstract: | Autophagy plays an important role in the cellular response to a variety of metabolic stress conditions thus contributing to the maintenance of intracellular homeostasis. Studies in yeast have defined the genetic components involved in the initiation of autophagy as well as the progression through the autophagic cascade. The yeast kinase Atg1 initiates autophagy in response to nutrient limitation in a TOR-dependent manner. The ulk family of genes encodes the mammalian ortholog of yeast Atg1. Our recent work using mouse embryonic fibroblast (MEF) cell lines deficient for both ulk1 and ulk2 has revealed that autophagy induction is more complex in mammals than in yeast. Furthermore, these data confirm the surprising finding that a byproduct of amino acid metabolism, ammonia, is a strong inducer of autophagy, as first shown by the Abraham laboratory. © 2012 Landes Bioscience. |
| Keywords: | signal transduction; metabolism; mammalia; animals; mice; cell viability; cell survival; models, biological; cell growth; astrocyte; saccharomyces cerevisiae; cancer cell; mammalian target of rapamycin; fibroblast; short survey; glucose; oxidative stress; amino acids; autophagy; cell metabolism; glutamine; citric acid cycle; ammonia; tor serine-threonine kinases; amino acid metabolism; osmotic stress; ulk1/2; ammonia formation |
| Journal Title: | Autophagy |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 1554-8627 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2012-01-01 |
| Start Page: | 122 |
| End Page: | 123 |
| Language: | English |
| DOI: | 10.4161/auto.8.1.18078 |
| PROVIDER: | scopus |
| PUBMED: | 22170154 |
| PMCID: | PMC3335992 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2012" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work