Only the strong survive: Therapeutic selective pressure drives medulloblastoma leptomeningeal metastasis Editorial

  

Authors:	He, F. Y.; Boire, A.
Title:	Only the strong survive: Therapeutic selective pressure drives medulloblastoma leptomeningeal metastasis
Abstract:	<p>Medulloblastoma (MB) is the most common malignant tumor in the central nervous system in childhood and regularly metastasizes to the leptomeninges following radiation therapy. Using patient-derived medulloblastoma models and genetically engineered mouse models, Nor et al. observed enhanced inflammation and infiltration of myeloid cells within the brain following irradiation. The authors identified inflammatory cytokines and the resulting breakdown of blood-brain barriers as the main culprits of MB leptomeningeal metastasis. This study demonstrated that targeting inflammation through the use of dexamethasone effectively reduced systemic inflammatory cytokines and the resulting radiation-induced leptomeningeal metastasis.</p>
Keywords:	medulloblastoma; radiation therapy; leptomeningeal metastasis
Journal Title:	Molecular Oncology
ISSN:	1878-0261
Publisher:	FEBS Press
Publication status:	Online ahead of print
Date Published:	2025-09-16
Online Publication Date:	2025-09-16
Language:	English
ACCESSION:	WOS:001573461800001
DOI:	10.1002/1878-0261.70125
PROVIDER:	wos
PUBMED:	40956872
Notes:	Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/229164