Phase II study of sorafenib in patients with metastatic or recurrent sarcomas Journal Article

Authors: Maki, R. G.; D'adamo, D. R.; Keohan, M. L.; Saulle, M.; Schuetze, S. M.; Undevia, S. D.; Livingston, M. B.; Cooney, M. M.; Hensley, M. L.; Mita, M. M.; Takimoto, C. H.; Kraft, A. S.; Elias, A. D.; Brockstein, B.; Blachere, N. E.; Edgar, M. A.; Schwartz, L. H.; Qin, L. X.; Antonescu, C. R.; Schwartz, G. K.
Article Title: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
Abstract: Purpose Since activity of sorafenib was observed in sarcoma patients in a phase I study, we performed a multicenter phase II study of daily oral sorafenib in patients with recurrent or metastatic sarcoma. Patients and Methods We employed a multiarm study design, each representing a sarcoma subtype with its own Simon optimal two-stage design. In each arm, 12 patients who received 0 to 1 prior lines of therapy were treated (0 to 3 for angiosarcoma and malignant peripheral-nerve sheath tumor). If at least one Response Evaluation Criteria in Solid Tumors (RECIST) was observed, 25 further patients with that sarcoma subtype were accrued. Results Between October 2005 and November 2007, 145 patients were treated; 144 were eligible for toxicity and 122 for response. Median age was 55 years; female-male ratio was 1.8: 1. The median number of cycles was 3. Five of 37 patients with angiosarcoma had a partial response (response rate, 14%). This was the only arm to meet the RECIST response rate primary end point. Median progression-free survival was 3.2 months; median overall survival was 14.3 months. Adverse events (typically dermatological) necessitated dose reduction for 61% of patients. Statistical modeling in this limited patient cohort indicated sorafenib toxicity was correlated inversely to patient height. There was no correlation between phosphorylated extracellular signal regulated kinase expression and response in six patients with angiosarcoma with paired pre- and posttherapy biopsies. Conclusion As a single agent, sorafenib has activity against angiosarcoma and minimal activity against other sarcomas. Further evaluation of sorafenib in these and possibly other sarcoma subtypes appears warranted, presumably in combination with cytotoxic or kinase-specific agents.
Keywords: imatinib; gastrointestinal stromal tumors; angiosarcoma; docetaxel; leiomyosarcoma; trial; kinase; growth; soft-tissue sarcomas; dermatofibrosarcoma protuberans; gemcitabine plus
Journal Title: Journal of Clinical Oncology
Volume: 27
Issue: 19
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2009-07-01
Start Page: 3133
End Page: 3140
Language: English
ACCESSION: ISI:000267454100013
DOI: 10.1200/jco.2008.20.4495
PMCID: PMC2716936
PUBMED: 19451436
Notes: --- - Proceedings Paper - "Source: Wos"
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MSK Authors
  1. Gary Schwartz
    343 Schwartz
  2. David R D'Adamo
    30 D'Adamo
  3. Lawrence H Schwartz
    275 Schwartz
  4. Cristina R Antonescu
    599 Antonescu
  5. Mark Allen Edgar
    45 Edgar
  6. Robert Maki
    199 Maki
  7. Li-Xuan Qin
    111 Qin
  8. Mary Louise Keohan
    60 Keohan
  9. Martee L Hensley
    211 Hensley