Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies Review
| Authors: | Weirauch, U.; Kreuz, M.; Birkenbihl, C.; Alb, M.; Quaranta, M.; Calzone, L.; Orozco-Ruiz, S.; Binder, S.; Fischer, L.; Clavreul, S.; Maguri, M.; Ferle, M.; Rade, M.; Azarias, G.; Hydren, J. R.; Jamarik, J.; Schwarz, D.; Sebestyen, Z.; Kuball, J.; Popp, G.; Antoine, C.; Knockaert, M.; Schoeder, C. T.; Fandrei, D.; Sanges, C.; Radvilas, V.; Gagelmann, N.; Rückert, M.; Penack, O.; Fricke, S.; Schmidt, A.; Ward, C.; Steinbeisser, C.; Van Gyseghem, J. M.; Niarakis, A.; Garderet, L.; Hudecek, M.; Neumuth, T.; Platzbecker, U.; Köhl, U.; Demlova, R.; Kremer, A.; Franke, S.; Fröhlich, H.; Merz, M.; Reiche, K.; On behalf of the CERTAINTY Consortium |
| Review Title: | Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies |
| Abstract: | In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs. |
| Keywords: | therapy; cells; car; cancer |
| Journal Title: | Npj Digital Medicine |
| Volume: | 8 |
| ISSN: | 2398-6352 |
| Publisher: | Nature Portfolio |
| Date Published: | 2025-08-01 |
| Start Page: | 493 |
| Language: | English |
| ACCESSION: | WOS:001542625700002 |
| DOI: | 10.1038/s41746-025-01809-6 |
| PROVIDER: | wos |
| PMCID: | PMC12316993 |
| PUBMED: | 40750653 |
| Notes: | Source: Wos |
