Molecular circuits for genomic recording of cellular events Journal Article
| Authors: | Chen, W.; Choi, J. |
| Article Title: | Molecular circuits for genomic recording of cellular events |
| Abstract: | Advances in precise genome editing are enabling genomic recordings of cellular events. Since the initial demonstration of CRISPR-based genome editing, the field of genomic recording has witnessed key strides in lineage recording, where clonal lineage relationships among cells are indirectly recorded as synthetic mutations. However, methods for directly recording and reconstructing past cellular events are still limited, and their potential for revealing new insights into cell fate decisions has yet to be realized. The field needs new sensing modules and genetic circuit architectures that faithfully encode past cellular states into genomic DNA recordings to achieve such goals. Here we review recently developed strategies to construct diverse sensors and explore how emerging synthetic biology tools may help to build molecular circuits for genomic recording of diverse cellular events. © 2025 Elsevier Ltd |
| Keywords: | review; nonhuman; cell fate; genomic dna; pharmacology; sensor; synthetic biology; human; crispr; gene editing; genomic recording; molecular circuits |
| Journal Title: | Trends in Genetics |
| ISSN: | 0168-9525 |
| Publisher: | Elsevier Inc. |
| Publication status: | Online ahead of print |
| Date Published: | 2025-01-01 |
| Online Publication Date: | 2025-01-01 |
| Language: | English |
| DOI: | 10.1016/j.tig.2025.04.004 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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