Selectivity and anti-tumor immune elevation by vascular-targeted photodynamic therapy of mouse orthotopic bladder cancer model Journal Article
| Authors: | Chen, J.; Kudinova, N.; Dubrovsky, R.; Thomas, J.; Nagar, K.; Nogueira, L.; Scherz, A.; Kim, K.; Coleman, J. |
| Article Title: | Selectivity and anti-tumor immune elevation by vascular-targeted photodynamic therapy of mouse orthotopic bladder cancer model |
| Abstract: | Vascular-targeted photodynamic therapy (VTP) with WST11 is a non-surgical tumor ablation approach that is currently being tested in a phase 3 clinical trial for the treatment of upper tract urothelial cancer. WST11-VTP utilizes illumination, leading to hypoxia, and production of free radicals followed by coagulative necrosis. Here, we tested the hypothesis that WST11-VTP can safely ablate muscle-invasive MB-49- luc bladder tumors in an orthotopic mouse model while sparing the surrounding normal tissue. For the safety study, normal mouse bladders were WST11-VTP treated. Fourteen days post-VTP granulomas in local areas around the ablation zone were noticed, which recovered after 44 days. MB49-luc orthotopic tumors at the muscle-invasive stage appeared to be effectively ablated by VTP 4–10 days post-treatment. The anti-tumor response was reflected in the increased invasion of CD4+, CD8+ T cells, myeloid CD11b+ cells, and NK cells in tumor tissue at 7 days post-therapy. Moreover, VTP therapy prolonged the survival of mice bearing orthotopic tumors compared with the untreated control. These results suggest that VTP can selectively ablate malignant tumors in the bladder and promote a robust anti-tumor response in a mouse model that can further augment the therapeutic outcome. © 2025 The Author(s). Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology. |
| Keywords: | bladder cancer; anti-tumor immunity; vascular-targeted photodynamic therapy; orthotopic mouse model |
| Journal Title: | Photochemistry and Photobiology |
| ISSN: | 0031-8655 |
| Publisher: | Wiley Blackwell |
| Publication status: | Online ahead of print |
| Date Published: | 2025-03-06 |
| Online Publication Date: | 2025-03-06 |
| Language: | English |
| DOI: | 10.1111/php.14048 |
| PROVIDER: | scopus |
| PUBMED: | 40051045 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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