Consideration of tumor genomics in the management of synchronous colorectal liver metastases Journal Article
| Authors: | Foster, D. S.; D'Angelica, M. I. |
| Article Title: | Consideration of tumor genomics in the management of synchronous colorectal liver metastases |
| Abstract: | Colorectal cancer with synchronous metastatic disease to the liver represents a particular challenge in multidisciplinary cancer care. Optimal management involves a combination of surgical resection, systemic, regional and/or targeted therapies; however, the order of and timing of specific therapies requires a nuanced understanding of the disease biology including tumor genomics. In the following article, we conducted a narrative review of the literature to critically examine existing data on the impact of tumor genomics in synchronous colorectal liver metastasis management. We provide a qualitative synthesis of the available literature and identify areas of particular interest for investigation moving forward. © 2025 Elsevier B.V., All rights reserved. |
| Keywords: | survival rate; gene mutation; gene; genetic association; transcriptomics; microsatellite instability; genomics; oncogene ras; colorectal liver metastases; tumor microenvironment; cancer prognosis; colorectal liver metastasis; human; article; raf gene; oncogenomics; tumor genomics; tumor mutational burden |
| Journal Title: | Surgery Open Science |
| Volume: | 27 |
| ISSN: | 2589-8450 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2025-09-01 |
| Start Page: | 106 |
| End Page: | 109 |
| Language: | English |
| DOI: | 10.1016/j.sopen.2025.07.009 |
| PROVIDER: | scopus |
| PMCID: | PMC12357274 |
| PUBMED: | 40822513 |
| DOI/URL: | |
| Notes: | Article -- MSK corresponding author is Michael D'Angelica -- Source: Scopus |
