Consideration of tumor genomics in the management of synchronous colorectal liver metastases Journal Article

   


Authors: Foster, D. S.; D'Angelica, M. I.
Article Title: Consideration of tumor genomics in the management of synchronous colorectal liver metastases
Abstract: Colorectal cancer with synchronous metastatic disease to the liver represents a particular challenge in multidisciplinary cancer care. Optimal management involves a combination of surgical resection, systemic, regional and/or targeted therapies; however, the order of and timing of specific therapies requires a nuanced understanding of the disease biology including tumor genomics. In the following article, we conducted a narrative review of the literature to critically examine existing data on the impact of tumor genomics in synchronous colorectal liver metastasis management. We provide a qualitative synthesis of the available literature and identify areas of particular interest for investigation moving forward. © 2025 Elsevier B.V., All rights reserved.
Keywords: survival rate; gene mutation; gene; genetic association; transcriptomics; microsatellite instability; genomics; oncogene ras; colorectal liver metastases; tumor microenvironment; cancer prognosis; colorectal liver metastasis; human; article; raf gene; oncogenomics; tumor genomics; tumor mutational burden
Journal Title: Surgery Open Science
Volume: 27
ISSN: 25898450
Publisher: Elsevier B.V.  
Date Published: 2025-01-01
Start Page: 106
End Page: 109
Language: English
DOI: 10.1016/j.sopen.2025.07.009
PROVIDER: scopus
PMCID: PMC12357274
PUBMED: 40822513
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105012589853&doi=10.1016%2Fj.sopen.2025.07.009&partnerID=40&md5=8ce618ce03e541427caf189d5526eb34
Notes: Article -- Source: Scopus
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