Osteoradionecrosis as a complication following post-operative intensity-modulated radiation therapy or proton therapy for oral cavity cancer Journal Article


Authors: Treechairusame, T.; Singh, A.; Dee, E. C.; Oh, J. H.; Zhang, P.; Xiong, J.; Aliotta, E.; Safavi, A. H.; Wu, Y.; Caineng, C.; Sine, K.; Mah, D.; Shim, A.; Lin, H.; Kang, J. J.; Tsai, C. J.; Gelblum, D. Y.; Yu, Y.; McBride, S.; Riaz, N.; Zakeri, K.; Chen, L.; Shamseddine, A.; Wong, W.; Dunn, L. A.; Michel, L. S.; Sherman, E. J.; Ho, A. L.; Huryn, J. M.; Yom, S. K.; Ganly, I.; Cracchiolo, J. R.; Cohen, M. A.; Wong, R. J.; Estilo, C. L.; Lee, N. Y.
Article Title: Osteoradionecrosis as a complication following post-operative intensity-modulated radiation therapy or proton therapy for oral cavity cancer
Abstract: Objective: To report the prevalence of osteoradionecrosis (ORN) in oral cavity (OC) cancer patients following intensity-modulation radiation therapy (IMRT) or proton therapy (PRT). Methods: A retrospective study was conducted on consecutive cohort of OC cancer patients treated with IMRT or PRT for squamous cell carcinoma (SCC). Patient information and treatment related variables were collected from medical records. Patients who developed ORN were uniformly graded using CTCAE v5. Cox proportional hazards model was used to compare risk factors between IMRT and PRT. Kaplan-Meier method was used to estimate the cumulative incidence (CI) of ORN. Results: A total of 479 OC SCC patients (426 treated with IMRT and 53 treated with PRT) were included in this study. The median follow-up time was 35 months (IQR, 17–68 months). The prevalence of ORN was similar between groups: 11% (47/426) in the IMRT group (21 Grade 1, 13 Grade 2, 13 Grade 3) and 11.3% (6/53) in the PRT group (2 Grade 1, 3 Grade 2, 1 Grade 3). The median time to ORN development was shorter following IMRT [13 months (IQR, 9–39)] compared to PRT [28 months (IQR, 4–42)].The 3-year CI of any grade ORN was 9.6 % and 11.4 % for IMRT and PRT (log-rank P-value = 0.550), respectively. On univariable analysis, smoking history (P = 0.072), tumor stage (P = 0.011), tumor with mandibular invasion (P = 0.007), and extent of mandibular intervention (P < 0.001) was associated with ORN development. On multivariable analysis, the extent of mandibular intervention remained a significant risk factor (P < 0.001). Conclusion: In this single-institution study, we found a similar prevalence of ORN following IMRT (11%) and PRT (11.3 %) in OC cancer patients. © 2025 Elsevier B.V., All rights reserved.
Keywords: adult; controlled study; aged; middle aged; cancer surgery; retrospective studies; major clinical study; intensity modulated radiation therapy; squamous cell carcinoma; carcinoma, squamous cell; cancer patient; cancer radiotherapy; cancer staging; follow up; radiation; radiotherapy dosage; radiotherapy; prevalence; cohort analysis; risk factors; smoking; retrospective study; risk factor; risk assessment; proportional hazards model; head and neck cancer; radiotherapy, intensity-modulated; dosimetry; surgery; kaplan meier method; epidemiology; mouth neoplasms; osteoradionecrosis; intensity-modulated radiation therapy; cumulative incidence; etiology; adverse event; oral cavity cancer; mouth squamous cell carcinoma; mouth tumor; proton therapy; tumor invasion; procedures; Common Terminology Criteria for Adverse Events; humans; human; male; female; article; radiographic parameter; eclipse (nuclear magnetic resonance scanner)
Journal Title: Oral Oncology
Volume: 168
ISSN: 1368-8375
Publisher: Elsevier Inc.  
Date Published: 2025-09-01
Start Page: 107581
Language: English
DOI: 10.1016/j.oraloncology.2025.107581
PUBMED: 40782527
PROVIDER: scopus
DOI/URL:
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Nancy Lee -- MSK author Caineng Cao's first and last names are reversed on the original publication -- Author Andy (JinSup) Shim is incorrectly affiliated with MSK on the original publication -- Source: Scopus
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MSK Authors
  1. Joseph M Huryn
    112 Huryn
  2. Daphna Y Gelblum
    229 Gelblum
  3. Cherry Estilo
    98 Estilo
  4. Loren Michel
    63 Michel
  5. Eric J Sherman
    349 Sherman
  6. Nadeem Riaz
    423 Riaz
  7. Nancy Y. Lee
    891 Lee
  8. Richard J Wong
    422 Wong
  9. Pengpeng Zhang
    181 Zhang
  10. Jung Hun Oh
    194 Oh
  11. Alan Loh Ho
    245 Ho
  12. Ian Ganly
    436 Ganly
  13. SaeHee Kim Yom
    44 Yom
  14. Jianping Xiong
    24 Xiong
  15. Sean Matthew McBride
    303 McBride
  16. Lara   Dunn
    142 Dunn
  17. Marc A Cohen
    142 Cohen
  18. Yao Yu
    118 Yu
  19. Winston Wong
    30 Wong
  20. Linda Chang Chen
    71 Chen
  21. Kaveh Zakeri
    85 Zakeri
  22. Yingzhi Wu
    9 Wu
  23. Annu Singh
    29 Singh
  24. Eric Aliotta
    18 Aliotta
  25. Edward Christopher Dee
    297 Dee
  26. Haibo Lin
    24 Lin
  27. Amir Safavi
    5 Safavi
  28. Caineng Cao
    1 Cao