Osteoradionecrosis as a complication following post-operative intensity-modulated radiation therapy or proton therapy for oral cavity cancer Journal Article


Authors: Treechairusame, T.; Singh, A.; Dee, E. C.; Oh, J. H.; Zhang, P.; Xiong, J.; Aliotta, E.; Safavi, A. H.; Wu, Y.; Caineng, C.
Article Title: Osteoradionecrosis as a complication following post-operative intensity-modulated radiation therapy or proton therapy for oral cavity cancer
Abstract: Objective: To report the prevalence of osteoradionecrosis (ORN) in oral cavity (OC) cancer patients following intensity-modulation radiation therapy (IMRT) or proton therapy (PRT). Methods: A retrospective study was conducted on consecutive cohort of OC cancer patients treated with IMRT or PRT for squamous cell carcinoma (SCC). Patient information and treatment related variables were collected from medical records. Patients who developed ORN were uniformly graded using CTCAE v5. Cox proportional hazards model was used to compare risk factors between IMRT and PRT. Kaplan-Meier method was used to estimate the cumulative incidence (CI) of ORN. Results: A total of 479 OC SCC patients (426 treated with IMRT and 53 treated with PRT) were included in this study. The median follow-up time was 35 months (IQR, 17–68 months). The prevalence of ORN was similar between groups: 11% (47/426) in the IMRT group (21 Grade 1, 13 Grade 2, 13 Grade 3) and 11.3% (6/53) in the PRT group (2 Grade 1, 3 Grade 2, 1 Grade 3). The median time to ORN development was shorter following IMRT [13 months (IQR, 9–39)] compared to PRT [28 months (IQR, 4–42)].The 3-year CI of any grade ORN was 9.6 % and 11.4 % for IMRT and PRT (log-rank P-value = 0.550), respectively. On univariable analysis, smoking history (P = 0.072), tumor stage (P = 0.011), tumor with mandibular invasion (P = 0.007), and extent of mandibular intervention (P < 0.001) was associated with ORN development. On multivariable analysis, the extent of mandibular intervention remained a significant risk factor (P < 0.001). Conclusion: In this single-institution study, we found a similar prevalence of ORN following IMRT (11%) and PRT (11.3 %) in OC cancer patients. © 2025 Elsevier B.V., All rights reserved.
Keywords: adult; controlled study; aged; middle aged; cancer surgery; retrospective studies; major clinical study; intensity modulated radiation therapy; squamous cell carcinoma; carcinoma, squamous cell; cancer patient; cancer radiotherapy; cancer staging; follow up; radiation; radiotherapy dosage; radiotherapy; prevalence; cohort analysis; risk factors; smoking; retrospective study; risk factor; risk assessment; proportional hazards model; head and neck cancer; radiotherapy, intensity-modulated; dosimetry; surgery; kaplan meier method; epidemiology; mouth neoplasms; osteoradionecrosis; intensity-modulated radiation therapy; cumulative incidence; etiology; adverse event; oral cavity cancer; mouth squamous cell carcinoma; mouth tumor; proton therapy; tumor invasion; procedures; Common Terminology Criteria for Adverse Events; humans; human; male; female; article; radiographic parameter; eclipse (nuclear magnetic resonance scanner)
Journal Title: Oral Oncology
Volume: 168
ISSN: 18790593
Publisher: Elsevier B.V.  
Date Published: 2025-01-01
Start Page: 107581
Language: English
DOI: 10.1016/j.oraloncology.2025.107581
PUBMED: 40782527
PROVIDER: scopus
DOI/URL:
Notes: Article -- Source: Scopus
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