Natural history of pancreatic cyst with diameter as solitary risk factor Journal Article
| Authors: | Choubey, A. P.; Alessandris, R.; Armstrong, M. T.; Chou, J.; D'Angelica, M. I.; Jarnagin, W. R.; Wei, A. C.; Rolston, V. S.; Schattner, M. A.; Soares, K. C.; MSKCC Pancreas Cyst Collaborative |
| Article Title: | Natural history of pancreatic cyst with diameter as solitary risk factor |
| Abstract: | BACKGROUND: Multiple pancreatic cyst surveillance guidelines include cyst diameter 3 cm or greater as a worrisome feature prompting surgical referral. STUDY DESIGN: This was a single-center retrospective review of patients with pancreatic cysts 3 cm or greater at diagnosis and no other worrisome features. Cyst progression was defined as the development of additional worrisome features, pancreatic cancer diagnosis, or pancreatectomy. Pseudocysts and biopsy-proven malignancies or non-intraductal papillary mucinous neoplasm cysts at initial consultation were excluded. RESULTS: Between 2010 and 2019, 89 patients met eligibility criteria with median age of 70.9 (21 to 91) years, cyst size of 3.5 (3.10 to 9.7) cm, and follow-up of 85.7 (30.8 to 139.3) months. Cyst progression or resection occurred in 13 during follow-up There were no cases of pancreatic cancer or high-grade dysplasia on postoperative pathology. Twelve patients (13%) died without evidence of progression. Cumulative incidence of progression from surveillance initiation was 3.4% (95% CI 0.9% to 8.8%) at 3 months, 5.6% (95% CI 2.1% to 11.9%) at 9 months, 9.0% (95% CI 4.2% to 16.2%) at 15 months, 11.2% (95% CI 5.7% to 18.8%) at 21 months, and 13.7% (95% CI 7.5% to 21.8%) at 57 months. CONCLUSIONS: Pancreatic cysts with a diameter 3 cm or greater as the sole worrisome feature can be safely monitored with low rates of progression during surveillance, and no incidence of cancer or high-grade dysplasia in our cohort. This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine |
| Keywords: | adult; aged; aged, 80 and over; middle aged; retrospective studies; young adult; pancreatic neoplasms; follow up; follow-up studies; pancreas cyst; risk factors; pathology; diagnostic imaging; retrospective study; risk factor; disease progression; diagnosis; pancreas tumor; pancreatectomy; surgery; disease exacerbation; pancreatic cyst; very elderly; humans; human; male; female |
| Journal Title: | Journal of the American College of Surgeons |
| Volume: | 241 |
| Issue: | 3 |
| ISSN: | 1072-7515 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2025-09-01 |
| Start Page: | 364 |
| End Page: | 369 |
| Language: | English |
| DOI: | 10.1097/xcs.0000000000001389 |
| PUBMED: | 40110866 |
| PROVIDER: | scopus |
| PMCID: | PMC12353199 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Kevin C. Soares -- Source: Scopus |
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