Point-of-care urine metabolomics test to diagnose colorectal cancers in low-and middle-income countries: A pilot controlled trial in southwestern Nigeria Journal Article
| Authors: | Adeomi, A. A.; Alatise, O. I.; Wishart, D.; MacKay, S.; Olasehinde, O.; Wuraola, F.; Adisa, A.; Mohammed, T.; Aderounmu, A.; Betiku, O. A.; Omoyiola, Z. O.; Adeleye, A. O.; Ogunleye, S. O.; Babatunde, O. J.; Ademakinwa, O. R.; Owoade, I. A.; Mobolaji, J.; Olcese, C.; Kahn, R.; Choonawala, N. R.; Fitzgerald, G.; Hosgood, H. D.; Kingham, T. P. |
| Article Title: | Point-of-care urine metabolomics test to diagnose colorectal cancers in low-and middle-income countries: A pilot controlled trial in southwestern Nigeria |
| Abstract: | PURPOSETo test the feasibility of a point-of-care (POC) real-time urine metabolomics test, evaluate its validity in diagnosing colorectal cancer (CRC) among at-risk patients, and assess the willingness of patients in Southwestern Nigeria to use and pay for the test.METHODSThis was a pilot-controlled trial carried out among 72 patients (34 cases and 38 controls) in southwestern Nigeria. The cases were those with histopathological diagnosis of CRC while controls were at-risk adults. The POC biosensor used a disposable chip and can be connected to a smart device using Bluetooth, and reported if the patient's urine contained metabolites consistent with CRC. We assessed validity of the test using sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPV), and prespecified a specificity of 50% with a goal of ≥80% sensitivity to estimate the potential of the test to half the referrals to colonoscopy. Additionally, we assessed perception toward the test and willingness to uptake the urine test using structured questionnaires.RESULTSThe overall sensitivity, specificity, PPV, and NPV for all respondents were 91.18%, 81.58%, 81.58%, and 91.18% respectively, with an area under the receiver operating characteristic curve of 0.86. With specificity fixed at 50%, the overall sensitivity for all respondents was 94.5%, and all stratifications had sensitivity >90%. Overall, 70 (98.6%) were satisfied with the urine-based CRC screening, and respondents were willing to pay a mean amount of 8,008.20 Naira (about $5.2 US dollars) for the test.CONCLUSIONOur urine metabolite early diagnosis POC test met our predetermined criteria for success and had high acceptance rates among Nigerian patients, supporting a future multi-institutional implementation trial assessing our ability to scale up utilization. © 2025 Elsevier B.V., All rights reserved. |
| Keywords: | adult; controlled study; aged; middle aged; major clinical study; case control study; case-control studies; sensitivity and specificity; colorectal cancer; controlled clinical trial; point-of-care systems; colorectal neoplasms; feasibility study; pilot study; pilot projects; colorectal tumor; diagnosis; urine; validity; urinalysis; patient attitude; predictive value; receiver operating characteristic; metabolomics; diagnostic test accuracy study; structured questionnaire; nigeria; procedures; point of care testing; point-of-care testing; humans; human; male; female; article; middle income country; low income country; point of care system |
| Journal Title: | JCO Global Oncology |
| Volume: | 11 |
| ISSN: | 2687-8941 |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2025-08-01 |
| Start Page: | e2500062 |
| Language: | English |
| DOI: | 10.1200/go-25-00062 |
| PUBMED: | 40768684 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Adeleye A. Adeomi -- Source: Scopus |
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