CD5 expression in marginal zone lymphoma does not predict inferior outcome and has similarities to indolent lymphomas Journal Article


Authors: Ghione, P.; Bantilan, K. S.; Joffe, E.; Palomba, M. L.; Noy, A.; Caron, P.; Hamlin, P.; Kumar, A.; Matasar, M.; Owens, C.; Moskowitz, A.; Falchi, L.; Straus, D.; Horwitz, S.; Salles, G.; Dogan, A.; Zelenetz, A. D.
Article Title: CD5 expression in marginal zone lymphoma does not predict inferior outcome and has similarities to indolent lymphomas
Abstract: The prognostic relevance of CD5 expression in marginal zone lymphoma (MZL) remains poorly characterized. We aimed to compare baseline characteristics and outcomes of patients with CD5+ MZL and CD5– historical matched controls. We hypothesized that patients with CD5+ MZL may have similarities to other CD5– expressing B-cell lymphomas, which may be informative when considering alternative therapeutic approaches for this MZL subgroup. We retrospectively analyzed 64 patients with CD5+ MZL and 137 CD5– MZL controls matched on age at diagnosis and sex. The CD5+ and CD5– cases did not differ in terms of mucosa assiociated lymphoid tissue (MALT)–lymphoma International Prognostic Index or incidence of nodal involvement. Bone marrow involvement was significantly more frequent in CD5+ patients than in CD5– patients (67.5% vs 47.2%; P = .048). Mutated immunoglobulin heavy chain variable region gene was more common in CD5+ patients (80.0%) than CD5– patients (64.0%), but this association was not significant (P = .327). Overall survival was calculated until death from any cause, disease-specific survival until lymphoma-related death, and time from diagnosis to first treatment was calculated either considering all interventions or only systemic treatments. None of these outcomes were associated with CD5 expression. © 2025 Elsevier B.V., All rights reserved.
Journal Title: Blood Neoplasia
Volume: 1
Issue: 4
ISSN: 2950-3280
Publisher: Elsevier Inc.  
Date Published: 2024-12-01
Start Page: 100031
Language: English
DOI: 10.1016/j.bneo.2024.100031
PROVIDER: scopus
PMCID: PMC12182842
PUBMED: 40552129
DOI/URL:
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Paola Ghione -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Ariela Noy
    373 Noy
  2. Maria Lia Palomba
    446 Palomba
  3. Steven M Horwitz
    668 Horwitz
  4. Andrew D Zelenetz
    784 Zelenetz
  5. Alison Moskowitz
    359 Moskowitz
  6. Paul Hamlin
    293 Hamlin
  7. Matthew J Matasar
    293 Matasar
  8. Philip C Caron
    102 Caron
  9. David J Straus
    361 Straus
  10. Anita Kumar
    198 Kumar
  11. Ahmet Dogan
    470 Dogan
  12. Colette Ngozi Owens
    80 Owens
  13. Erel Joffe
    85 Joffe
  14. Paola Ghione
    91 Ghione
  15. Lorenzo Falchi
    134 Falchi
  16. Gilles Andre Salles
    307 Salles