Identifying novel biomarkers using proteomics to predict cancer-associated thrombosis Review
| Authors: | Turizo, M. J. F.; Patell, R.; Zwicker, J. I. |
| Review Title: | Identifying novel biomarkers using proteomics to predict cancer-associated thrombosis |
| Abstract: | Comprehensive protein analyses of plasma are made possible by high-throughput proteomic screens, which may help find new therapeutic targets and diagnostic biomarkers. Patients with cancer are frequently affected by venous thromboembolism (VTE). The limited predictive accuracy of current VTE risk assessment tools highlights the need for new, more targeted biomarkers. Although coagulation biomarkers for the diagnosis, prognosis, and treatment of VTE have been investigated, none of them have the necessary clinical validation or diagnostic accuracy. Proteomics holds the potential to uncover new biomarkers and thrombotic pathways that impact the risk of thrombosis. This review explores the fundamental methods used in proteomics and focuses on particular biomarkers found in VTE and cancer-associated thrombosis. |
| Keywords: | biomarkers; protein; proteomics; assay; thrombosis; expression; identification; risk-assessment; recurrent venous thromboembolism; d-dimer levels; aptamers; technologies; cancer-associated thrombosis |
| Journal Title: | Bleeding, Thrombosis and Vascular Biology |
| Volume: | 3 |
| Issue: | Suppl. 1 |
| ISSN: | 2785-5309 |
| Publisher: | Pagepress |
| Date Published: | 2024-01-01 |
| Start Page: | 120 |
| Language: | English |
| ACCESSION: | WOS:001537957200015 |
| DOI: | 10.4081/btvb.2024.120 |
| PROVIDER: | wos |
| PMCID: | PMC11143428 |
| PUBMED: | 38828226 |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Jeffrey Zwicker -- Source: Wos |
