Allogeneic hematopoietic cell donor selection: Contemporary guidelines from the NMDP/CIBMTR Review


Authors: Jimenez Jimenez, A. M.; Spellman, S. R.; Politikos, I.; McCurdy, S. R.; Devine, S. M.; Malki, M. M. A.; Bolon, Y. T.; Lee, S. J.; Dehn, J.; Pidala, J.; Maiers, M.; Askar, M.; Malmberg, C.; Auletta, J. J.; Stefanski, H.; Broglie, L.; Qayed, M.; Horwitz, M.; Wilder, J. S.; Gooptu, M.; Mehta, R. S.; Fernandez-Viña, M.; Shaw, B. E.; Shaffer, B. C.
Review Title: Allogeneic hematopoietic cell donor selection: Contemporary guidelines from the NMDP/CIBMTR
Abstract: Allogeneic hematopoietic cell transplantation (HCT) remains a curative therapy for many patients with hematologic malignancies, bone marrow failure syndromes, inborn errors of immunity and metabolic disorders. Current donor selection strategies typically prioritize the selection of an HLA-matched donor over HLA mismatched (“alternative”) donor sources, with a hierarchical approach to the donor search. More recent data challenge this rubric, particularly in the context of novel graft-versus-host disease (GVHD) prophylaxis strategies that demonstrate improved outcomes in alternative donor HCT recipients. In this setting, an increased emphasis on non-HLA factors (both donor characteristics and systemic factors) in determining donor selection is now feasible. In this guideline, we review recent evidence from prospective clinical trials as well as high-quality observational studies and provide expert panel recommendations on donor selection algorithms and prioritization in the era of novel GVHD prophylaxis. We then highlight important questions still to be answered in our field. © 2025 The Authors
Keywords: adult; controlled study; review; nonhuman; bone marrow; transplantation; hematologic malignancy; drug combination; algorithm; prophylaxis; graft versus host reaction; hematopoietic cell; graft rejection; clinical practice guideline; drug therapy; observational study; donor selection; guidelines; metabolic disorder; therapy; hla system; prevention; bone marrow depression; allogeneic; human; search strategy
Journal Title: Transplantation and Cellular Therapy
ISSN: 2666-6375
Publisher: Elsevier Inc.  
Publication status: Online ahead of print
Date Published: 2025-07-05
Online Publication Date: 2025-07-05
Language: English
DOI: 10.1016/j.jtct.2025.07.004
PUBMED: 40619101
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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  1. Brian Carl Shaffer
    175 Shaffer
  2. Ioannis   Politikos
    107 Politikos