Mucin-targeted antibodies for ovarian cancer Review
| Authors: | Lawson, S. A.; Lewis, J. S. |
| Review Title: | Mucin-targeted antibodies for ovarian cancer |
| Abstract: | Ovarian cancer remains a leading cause of gynecologic cancer mortality, driven in part by late-stage diagnoses and high recurrence rates. Among emerging molecular targets, mucins—highly glycosylated transmembrane glycoproteins overexpressed and aberrantly glycosylated in epithelial ovarian cancers—have garnered increasing interest for both imaging and therapeutic strategies. This review highlights the expression profiles and clinical implications of key mucins (MUC1, MUC16) and evaluates antibody-based modalities that leverage these targets for enhanced tumor detection and treatment. We discuss the current landscape of therapeutic strategies, including monoclonal antibodies, antibody-drug conjugates, bispecific antibodies, and radioimmunotherapy, with emphasis on recent preclinical and clinical advances. We also examine the role of mucin-targeted antibodies in imaging and the integration of theranostic platforms. Key challenges such as antigen heterogeneity, immunogenicity, and tumor penetration are addressed, along with future directions for optimizing mucin-directed therapies. Together, these efforts underscore the ever-expanding potential of mucin-targeted immunotherapy to improve outcomes for patients with ovarian cancer. © 2025 Elsevier Inc. |
| Journal Title: | Seminars in Nuclear Medicine |
| ISSN: | 0001-2998 |
| Publisher: | Elsevier Inc. |
| Publication status: | Online ahead of print |
| Date Published: | 2025-07-03 |
| Online Publication Date: | 2025-07-03 |
| Language: | English |
| DOI: | 10.1053/j.semnuclmed.2025.06.007 |
| PROVIDER: | scopus |
| PMCID: | PMC12233146 |
| PUBMED: | 40615275 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Jason S. Lewis -- Source: Scopus |
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