Platelet-rich plasma treatment for endocrine-induced alopecia and persistent chemotherapy-induced alopecia in breast cancer survivors: A randomized, controlled, pilot study Journal Article

  

Authors:	Rossi, A.; Pan, A.; Menzer, C.; Lavin, L.; Aleissa, S.; Aleisa, A.; Alshaikh, H.; Dranitsaris, G.; Dusza, S.; Bravo, C.; Lacouture, M. E.
Article Title:	Platelet-rich plasma treatment for endocrine-induced alopecia and persistent chemotherapy-induced alopecia in breast cancer survivors: A randomized, controlled, pilot study
Abstract:	BACKGROUNDPlatelet-rich plasma (PRP) shows potential in treating androgenetic alopecia but lacks evidence for endocrine-induced alopecia (EIA) or persistent chemotherapy-induced alopecia (pCIA).OBJECTIVETo evaluate safety and efficacy of PRP in breast cancer survivors with EIA or pCIA.METHODSIn this single-center, randomized, controlled trial, EIA and pCIA patients received PRP injections on one side of their scalp monthly for 3 months. Evaluations occurred at baseline and at week 12, followed by an optional cross-arm at week 24. The primary outcome was difference in global assessment scale (GAS) at week 12, assessed by a blinded investigator. Secondary outcomes included adverse events, hair-related quality of life, trichoscopic data, and circulating tumor cell (CTC) assay.RESULTSFifteen EIA and 12 pCIA patients enrolled. GAS improved from baseline to week 12 (+1.2 each, p <.001) but not statistically significant between treated and untreated sides (p >.05). Hair density increased for both sides (+21 and +16 hairs/cm2, respectively, p <.05), without difference between the sides (p >.05). Quality of life showed no improvement (41.1-39.4, p >.05). Adverse events included grade 1 to grade 3 scalp pain. Two of 12 CTC assays detected malignant cells in PRP, but no tumor seeding events were observed.CONCLUSIONPRP may increase hair density in EIA and pCIA patients and showed no adverse cancer outcomes or tumor seeding. Results may be confounded by possible PRP diffusion in split-scalp study design.ClinicalTrials.gov IDNCT04459650. © 2025 by the American Society for Dermatologic Surgery, Inc.
Journal Title:	Dermatologic Surgery
ISSN:	1076-0512
Publisher:	Lippincott Williams & Wilkins
Publication status:	Online ahead of print
Date Published:	2025-07-08
Online Publication Date:	2025-07-08
Language:	English
DOI:	10.1097/dss.0000000000004755
PROVIDER:	scopus
PUBMED:	40626588
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-105010279024&doi=10.1097%2fDSS.0000000000004755&partnerID=40&md5=7468399c631f5fc1550b989afdfb30fa
Notes:	Article -- MSK corresponding author is Anthony Rossi -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/227434