Evolving concepts in adjuvant/neoadjuvant therapy for resectable pancreas cancer Review

   


Authors: Bryant, J. M.; Ruffolo, L.; Soares, K.; Hoffe, S.; Lowy, A. M.
Review Title: Evolving concepts in adjuvant/neoadjuvant therapy for resectable pancreas cancer
Abstract: Despite advances in multidisciplinary oncology care, curing patients diagnosed with pancreatic duct adenocarcinoma (PDAC) remains all too uncommon. In this Review, we discuss evolving concepts to guide the care of patients with operable PDAC, focusing on adjuvant and neoadjuvant systemic therapies, the ever-controversial topic of radiation therapy, and the emerging role of cancer vaccines. Given the promise of biomarkers to better predict therapeutic response, the development of KRAS inhibitors, our ability to deliver higher doses of radiation therapy more precisely and safely, and the technology to rapidly produce highly personalized cancer vaccines, there is reason to expect that the guidelines for the care of our patients with operable PDAC will change rapidly in the next few years. © 2025, Bryant et al.
Keywords: adult; treatment response; review; systemic therapy; adjuvant therapy; pancreas cancer; chemotherapy, adjuvant; neoadjuvant therapy; pancreatic neoplasms; biological marker; radiotherapy; carcinoma, pancreatic ductal; practice guideline; pathology; cancer vaccine; cancer vaccines; adjuvant chemotherapy; pancreas tumor; cancer immunization; clinical practice guideline; drug therapy; therapy; pancreatic ductal carcinoma; humans; human; female
Journal Title: Journal of Clinical Investigation
Volume: 135
Issue: 14
ISSN: 0021-9738
Publisher: American Society for Clinical Investigation  
Date Published: 2025-07-15
Start Page: e191944
Language: English
DOI: 10.1172/jci191944
PUBMED: 40662364
PROVIDER: scopus
PMCID: PMC12259248
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105010685552&doi=10.1172%2fJCI191944&partnerID=40&md5=22c961e9afe2047cd54ee7489759e0c5
Notes: Review -- MSK corresponding author is Kevin Soares -- Source: Scopus
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MSK Authors
  1. Kevin Cerqueira Soares
    139 Soares
  2. Luis Ignacio Ruffolo
    1 Ruffolo
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