RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition Editorial
| Authors: | Weis, K.; Abdel-Wahab, O. |
| Title: | RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition |
| Abstract: | In this issue of Cell Chemical Biology, Fan et al.1 identify that mutations in the ribosomal protein RPL22 confer sensitivity to RNA polymerase I inhibitors. RPL22 regulates MDM4 function and cell death via splicing of the MDM4 mRNA. These findings connect ribosome biogenesis with RNA splicing through RPL22. © 2025 Elsevier Ltd |
| Keywords: | note; endometrium cancer; allele; enzyme inhibition; ovary cancer; rna translation; rna splicing; ribosome protein; biogenesis; dna directed rna polymerase; ribosome; author; vulnerability; immune checkpoint inhibitor; physiological stress; human; cancer cell line; t cell acute lymphoblastic leukemia |
| Journal Title: | Cell Chemical Biology |
| Volume: | 32 |
| Issue: | 7 |
| ISSN: | 2451-9456 |
| Publisher: | Cell Press |
| Date Published: | 2025-07-17 |
| Start Page: | 899 |
| End Page: | 901 |
| Language: | English |
| DOI: | 10.1016/j.chembiol.2025.06.001 |
| PROVIDER: | scopus |
| PUBMED: | 40680725 |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
