Prostate cancer recurrence due to isolated testicular metastases detected by PSMA PET/CT Journal Article
| Authors: | de Oliveira Taveira, M.; Razmaria, A. A.; Schoder, H.; Yeh, R. |
| Article Title: | Prostate cancer recurrence due to isolated testicular metastases detected by PSMA PET/CT |
| Abstract: | Prostate cancer is the most common solid malignancy to metastasize to the testicles, although testicular metastases remain rare and are often discovered only postmortem. Methods: Retrospective analysis of 95 68Ga-prostate-specific membrane antigen (PSMA) PET/CT reports from September 2016 to July 2024 using scrotal region search terms identified 30 patients with indeterminate findings and 6 patients with pathology-confirmed testicular metastases. Data on imaging, pathology, clinical outcomes, and prostate-specific antigen values were reviewed. Results: 68Ga-PSMA PET/CT detected isolated testicular metastases in 6 patients with M0 castrate-sensitive prostate cancer after maximal pelvic therapy who were imaged because of rising prostate-specific antigen levels. Three of the 6 patients did not have ultrasound abnormalities. Five of the 6 patients were treated with orchiectomy and had durable responses (median follow-up, 33 mo; range, 10–58 mo). Conclusion: Including the testes in field of view of the PSMA PET scan may avoid false-negative results. 68Ga-PSMA–avid testicular and peritesticular lesions may indicate metastasis even with a negative ultrasound. Orchiectomy can result in durable remissions for these patients. COPYRIGHT © 2025 by the Society of Nuclear Medicine and Molecular Imaging. |
| Keywords: | adult; clinical article; aged; middle aged; retrospective studies; case report; cancer patient; cancer radiotherapy; cancer staging; prostate specific antigen; metabolism; metastasis; recurrence; pathology; diagnostic imaging; retrospective study; prostate cancer; prostatic neoplasms; prostate tumor; testis tumor; testicular neoplasms; recurrent disease; orchiectomy; testis cancer; scrotum; glutamate carboxypeptidase ii; gallium; clinical outcome; edetic acid; gallium radioisotopes; humans; human; male; article; testicular metastasis; positron emission tomography-computed tomography; positron emission tomography computed tomography; gallium 68 psma-11; gallium isotopes; psma pet/ct |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 66 |
| Issue: | 6 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2025-06-02 |
| Start Page: | 892 |
| End Page: | 895 |
| Language: | English |
| DOI: | 10.2967/jnumed.124.269361 |
| PUBMED: | 40210421 |
| PROVIDER: | scopus |
| PMCID: | PMC12175991 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Mateus de Oliveira Taveira -- Source: Scopus |
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