Lung cancer and cardiovascular disease: Common pathophysiology and treatment-emergent toxicity Review
| Authors: | El-Rayes, M.; Nardi Agmon, I.; Yu, C.; Osataphan, N.; Yu, H. A.; Hope, A.; Sacher, A.; Yu, A. F.; Abdel-Qadir, H.; Thavendiranathan, P. |
| Review Title: | Lung cancer and cardiovascular disease: Common pathophysiology and treatment-emergent toxicity |
| Abstract: | Among patients with cancer, those with lung cancer have the highest prevalence of pre-existing cardiovascular disease (CVD) and the highest risk of cardiovascular events postdiagnosis. This is driven by shared risk factors, particularly smoking and socioeconomic factors, and common biology. Furthermore, multimodality therapies for lung cancer, including surgery, radiation, chemotherapy, immunotherapy, and targeted therapy, are associated with CVD. Improvements in prevention, screening, and therapy for lung cancer have led to improved cancer survival, increasing the relevance of CVD for overall survival and quality of life. This review provides an overview of lung cancer and its treatment and discusses drivers of CVD, risk assessment, surveillance, prevention, and treatment strategies. © 2025 The Authors |
| Keywords: | cancer survival; overall survival; review; pathophysiology; chemotherapy; quality of life; radiotherapy; prevalence; lung cancer; smoking; risk factor; risk assessment; cardiovascular disease; radiation therapy; targeted therapy; drug therapy; socioeconomics; human; cardio-oncology |
| Journal Title: | JACC: CardioOncology |
| Volume: | 7 |
| Issue: | 4 |
| ISSN: | 2666-0873 |
| Publisher: | American College of Cardiology |
| Date Published: | 2025-06-01 |
| Start Page: | 325 |
| End Page: | 344 |
| Language: | English |
| DOI: | 10.1016/j.jaccao.2025.05.003 |
| PROVIDER: | scopus |
| PMCID: | PMC12228138 |
| PUBMED: | 40537184 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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