| Abstract: |
Data from in vitro and animal studies suggest that asciminib, the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP), synergizes with adenosine triphosphate (ATP)-competitive tyrosine kinase inhibitors (TKIs) to prevent emergence of and overcome resistance. Combination therapy may provide new treatment options for patients with chronic myeloid leukemia (CML) with suboptimal responses to ATP-competitive TKI monotherapy. Preliminary analysis of asciminib combined with nilotinib, imatinib, or dasatinib in a phase 1 dose-escalation study suggested promising efficacy and safety for patients with CML in chronic phase or accelerated phase treated with prior ATP-competitive TKIs; herein, we present final results from the 3 combination therapy arms. Asciminib, in combination with ATP-competitive TKIs, demonstrated rapid efficacy offset by a decreased tolerability compared with asciminib monotherapy. Based on these safety, tolerability, and preliminary efficacy results, asciminib 40 mg twice daily (BID) plus nilotinib 300 mg BID, asciminib 40 or 60 mg once daily (QD) plus imatinib 400 mg QD, and asciminib 80 mg QD plus dasatinib 100 mg QD were identified as recommended doses for expansion. The maximum tolerated dose was reached at asciminib 60 mg QD plus imatinib 400 mg QD and was not reached with asciminib plus nilotinib or dasatinib. © The Author(s) 2025. |
| Keywords: |
adult; controlled study; aged; middle aged; young adult; major clinical study; clinical trial; fatigue; neutropenia; drug withdrawal; hypertension; antineoplastic agent; imatinib; multiple cycle treatment; protein kinase inhibitor; thrombocytopenia; antineoplastic combined chemotherapy protocols; cohort analysis; pathology; dasatinib; chronic myeloid leukemia; pyrimidines; protein kinase inhibitors; pyrazole derivative; pyrazoles; pleura effusion; phase 1 clinical trial; drug therapy; nilotinib; pyrimidine derivative; leukemia, myelogenous, chronic, bcr-abl positive; cerebrovascular accident; imatinib mesylate; nicotinamide; angina pectoris; bosutinib; niacinamide; ponatinib; humans; human; male; female; article; asciminib; radotinib; leukemia, myeloid, accelerated phase; cerebral atherosclerosis
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