Breast cancer recurrence after cryoablation in patients who are poor surgical candidates or who refuse surgery Journal Article
| Authors: | Jean, J.; Jochelson, M. S.; Moo, T. A.; Solomon, S. B.; Bryce, Y. |
| Article Title: | Breast cancer recurrence after cryoablation in patients who are poor surgical candidates or who refuse surgery |
| Abstract: | Purpose: To evaluate in-breast recurrence rates after cryoablation in patients with primary breast cancer who were poor surgical candidates or refused surgery. Materials and Methods: Patients with primary breast cancer who were poor surgical candidates or who refused surgery and were treated with cryoablation at a single academic cancer center between October 2018 and June 2023 were retrospectively reviewed. Of the 60 treated patients, 45 had invasive ductal carcinoma, 6 had invasive lobular carcinoma, 2 had multicentric ductal carcinoma in situ, and 7 had other histology. Tumor size ranged from 0.3 to 9 cm, with a mean of 2.7 cm. Recurrence was defined as new tumor or regrowth of residual tumor in the ipsilateral breast. Results: With a mean follow-up of 21 months and median follow-up of 9.8 months, there was a recurrence rate of 10% (6 of 60 patients). Patients in the recurrence group had more poorly differentiated disease than those in the nonrecurrence group (66.7% vs 22.2%; P =.038). Tumor size did not differ between nonrecurrence and recurrence groups (nonrecurrence group mean, 2.7 cm [SD ± 2.6]; recurrence group mean, 2.5 cm [SD ± 1.0]; P =.506). Patients who were treated with palliative intent rather than curative intent were significantly older (79.7 years [SD ± 12.2] vs 72.5 years [SD ± 11.3]; P =.032). Conclusions: Cryoablation can be considered a treatment option in patients who are poor surgical candidates or who refuse surgery, with a 10% recurrence rate at a mean follow-up of 21 months in this retrospective review that included patients with tumors up to 9 cm, unfavorable pathology, and multicentric disease. © 2025 |
| Keywords: | cancer chemotherapy; human tissue; aged; primary tumor; major clinical study; histopathology; cancer radiotherapy; recurrence risk; follow up; antineoplastic agent; cancer palliative therapy; breast cancer; tumor volume; retrospective study; minimal residual disease; cryoablation; invasive ductal carcinoma; very elderly; human; article; breast cancer recurrence; ductal breast carcinoma in situ; invasive lobular breast carcinoma |
| Journal Title: | Journal of Vascular and Interventional Radiology |
| Volume: | 36 |
| Issue: | 6 |
| ISSN: | 1051-0443 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2025-06-01 |
| Start Page: | 971 |
| End Page: | 978 |
| Language: | English |
| DOI: | 10.1016/j.jvir.2025.01.048 |
| PUBMED: | 39909175 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- Source: Scopus |
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