The surgical management of intracranial metastasis secondary to follicular cell-derived thyroid carcinoma Journal Article
| Authors: | Harries, V.; Eagan, A.; Tuttle, R. M.; Shaha, A. R.; Wong, R. J.; Shah, J. P.; Patel, S. G.; Brennan, C.; Ganly, I. |
| Article Title: | The surgical management of intracranial metastasis secondary to follicular cell-derived thyroid carcinoma |
| Abstract: | Background: Intracranial metastases (ICM) from follicular cell-derived thyroid carcinoma (FCDTC) are rare and are associated with a poor prognosis. The objective of this study is to report our experience in the surgical management of patients with ICM secondary to FCDTC. Methods: Patients with FCDTC who underwent surgical resection of an ICM were identified at our institution from 1998 to 2018. Results: Thirty-two patients were included in this study. Nineteen patients (59%) had involvement of the brain parenchyma only, 8 (25%) had a dural-based metastasis, 3 (9%) had a calvarial metastasis with dural extension, and 2 (6%) had a skull base metastasis with dural extension. In patients who had an R0-1 resection, the estimated lesional control at the site of resection was 91% at 3 years. However, overall ICM control was 37% at 3 years due to the progression of other ICM lesions. The 1-year disease-specific survival (DSS) was 87% and 5-year DSS was 37%. Conclusions: ICM management in FCDTC is based on the size, number, and location of metastatic lesions. Complete resection of ICM may provide lesional control at the site of resection, however, DSS is poor due to the presence of other ICMs and metastases at multiple distant sites. © 2024 Wiley Periodicals LLC. |
| Keywords: | adult; clinical article; controlled study; human tissue; aged; middle aged; excision; primary tumor; survival rate; retrospective studies; young adult; overall survival; histopathology; mortality; bone metastasis; cancer staging; nuclear magnetic resonance imaging; brain tumor; follow up; brain neoplasms; follow-up studies; metastasis; tumor volume; pathology; retrospective study; distant metastasis; brain; surgery; thyroid cancer; thyroid carcinoma; thyroid neoplasms; stereotactic radiosurgery; thyroid papillary carcinoma; thyroid tumor; adenocarcinoma, follicular; thyroid surgery; follicular carcinoma; thyroid follicular carcinoma; whole brain radiotherapy; parenchyma; thermal ablation; intracranial metastasis; hürthle cell carcinoma; distant; intracranial; poorly differentiated thyroid cancer; cancer prognosis; ovary follicle cell; humans; prognosis; human; male; female; article; thyroid cancer, follicular |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 131 |
| Issue: | 2 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2025-02-01 |
| Start Page: | 316 |
| End Page: | 324 |
| Language: | English |
| DOI: | 10.1002/jso.27883 |
| PUBMED: | 39328128 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Ian Ganly -- Source: Scopus |
