Aggressive malignant ossifying fibromyxoid tumor with a rare PHF1::FOXR2 fusion: A case report and literature review Journal Article

  


Authors: Syrnioti, A.; Chatzopoulos, K.; DiNapoli, S.; Sukhadia, P.; Linos, K.
Article Title: Aggressive malignant ossifying fibromyxoid tumor with a rare PHF1::FOXR2 fusion: A case report and literature review
Abstract: Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain origin, exhibiting a wide clinical and morphological spectrum. It ranges from benign forms, which typically behave indolently, to malignant lesions with significant recurrence and metastatic potential. The majority of OFMTs harbor PHF1 gene rearrangements, with EP400 being the most common fusion partner. Herein, we present a patient with malignant metastatic OFMT, with the very rare PHF1::FOXR2 fusion, and discuss the potential clinical implications of this genetic alteration. © The Author(s) 2024.
Keywords: phf1; ossifying fibromyxoid tumor; foxr2
Journal Title: International Journal of Surgical Pathology
Volume: 33
Issue: 4
ISSN: 1066-8969
Publisher: Sage Publications  
Date Published: 2025-06-01
Start Page: 1010
End Page: 1015
Language: English
DOI: 10.1177/10668969241295349
PUBMED: 39552609
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85209398531&doi=10.1177%2f10668969241295349&partnerID=40&md5=1ee7370d8f7fc14954d740d461540b20
Notes: Article -- MSK corresponding author is Konstantinos Linos Source: Scopus
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MSK Authors
  1. Konstantinos Linos
    53 Linos
  2. Purvil Sukhadia
    28 Sukhadia
  3. Sara DiNapoli
    23 DiNapoli
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