Moving from the background toward the spotlight: A critical review of radiation therapy for locally advanced pancreas cancer Review
| Authors: | Chuong, M. D.; Ashman, J.; Jethwa, K.; Kharofa, J.; Kim, H.; Koay, E.; Ludmir, E.; Miller, E.; Nelson, B.; Reyngold, M.; Sanford, N.; Chang, D. |
| Review Title: | Moving from the background toward the spotlight: A critical review of radiation therapy for locally advanced pancreas cancer |
| Abstract: | Radiation therapy (RT) for locally advanced pancreatic cancer (LAPC) continues to be controversial. Advances in both systemic therapy and RT techniques have changed the landscape of LAPC management in recent years. Clinical outcomes of ablative RT have been encouraging, and randomized clinical trials may clarify the role of RT for LAPC. We present a contemporary critical review of key aspects regarding optimal patient selection, radiation dose escalation techniques, novel radiosensitizers and radioprotectors, and treatment response assessment for LAPC. © 2025 Elsevier Inc. |
| Keywords: | treatment response; review; patient selection; systemic therapy; pancreas cancer; pancreatic neoplasms; randomized controlled trial; radiotherapy dosage; radiotherapy; pathology; pancreas tumor; radiation-protective agents; drug therapy; radiosensitizing agent; radiation-sensitizing agents; therapy; randomized clinical trials; radioprotective agent; clinical outcome; radioprotectors; dose escalation; radiation dose escalation; humans; human; locally advanced pancreatic cancers; cancer management; critical review; radiosensitizers |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 122 |
| Issue: | 2 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2025-06-01 |
| Start Page: | 294 |
| End Page: | 312 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2025.02.022 |
| PUBMED: | 40032056 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
