Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy Journal Article

   

Authors:	Barrios, J.; Porter, E.; Capaldi, D. P. I.; Upadhaya, T.; Chen, W. C.; Perks, J. R.; Apte, A.; Aristophanous, M.; LoCastro, E.; Hsu, D.; Stone, P. H.; Villanueva-Meyer, J. E.; Valdes, G.; Jiang, F.; Maddalena, M.; Ballangrud, A.; Prezelski, K.; Lin, H.; Sun, J. Y.; Aldin, M. A. K.; Chau, O. W.; Ziemer, B.; Seaberg, M.; Sneed, P. K.; Nakamura, J. L.; Boreta, L. C.; Fogh, S. E.; Raleigh, D. R.; Chew, J.; Vasudevan, H.; Cha, S.; Hess, C.; Fragoso, R.; Shultz, D. B.; Pike, L.; Hervey-Jumper, S. L.; Tsang, D. S.; Theodosopoulos, P.; Cooke, D.; Benedict, S. H.; Sheng, K.; Seuntjens, J.; Coolens, C.; Deasy, J. O.; Braunstein, S.; Morin, O.
Article Title:	Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy
Abstract:	Brain metastases are a frequent and debilitating manifestation of advanced cancer. Here, we collect and analyze neuroimaging of 3,065 cancer patients with 13,067 brain metastases, representing an extensive collection for research. We find that metastases predominantly localize to high perfusion areas near the grey-white matter junction, but also identify notable differences depending on the primary cancer histology as well as brain regions which do not conform to this relationship. Lung and breast cancers, in contrast to melanoma, frequently metastasize to the cerebellum, hinting at biological pathways of spread. Additionally, the deep brain structures are relatively spared from metastasis, regardless of primary cancer type. Leveraging this data, we propose a probabilistic brain metastasis risk model to enhance the therapeutic ratio of whole-brain radiotherapy by targeting high risk areas while preserving cortical and subcortical brain regions of functional significance and low metastasis risk, potentially reducing the cognitive side effects of therapy. © The Author(s) 2025.
Keywords:	adult; aged; middle aged; clinical trial; neuroimaging; nuclear magnetic resonance imaging; brain tumor; brain neoplasms; magnetic resonance imaging; radiotherapy; pathology; diagnostic imaging; breast neoplasms; histology; brain; multicenter study; breast tumor; health risk; therapy; personalized medicine; book; atlases as topic; procedures; cancer; humans; human; male; female; precision medicine; spatial data
Journal Title:	Nature Communications
Volume:	16
ISSN:	2041-1723
Publisher:	Nature Publishing Group
Date Published:	2025-05-15
Start Page:	4536
Language:	English
DOI:	10.1038/s41467-025-59584-7
PUBMED:	40374598
PROVIDER:	scopus
PMCID:	PMC12081687
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-105005263210&doi=10.1038%2fs41467-025-59584-7&partnerID=40&md5=c5992c4c111eb265d89f351187f81943
Notes:	Article -- Erratum issued, see DOI: 10.1038/s41467-025-60522-w -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/225514