Identifying baseline rectal MRI features as predictive indicators for local recurrence and metastatic disease in rectal cancer treated with surgical resection and neoadjuvant therapy or surgical resection alone Journal Article

   

Authors:	El Homsi, M.; Javed-Tayyab, S.; Charbel, C.; Golia Pernicka, J. S.; Paroder, V.; White, C.; Capanu, M.; Rodriguez, L.; Gangai, N.; Petkovska, I.
Article Title:	Identifying baseline rectal MRI features as predictive indicators for local recurrence and metastatic disease in rectal cancer treated with surgical resection and neoadjuvant therapy or surgical resection alone
Abstract:	Background: To identify baseline rectal MRI characteristics that may serve as predictive factors for recurrence in patients with rectal adenocarcinoma after surgical resection. Methods: This retrospective, single-center study included 269 consecutive patients (median age, 55 years [interquartile range, 47–65]; 144 men and 125 women) diagnosed with rectal cancer from January 2015–December 2017 who underwent baseline rectal MRI followed by surgical resection. MRI characteristics were collected from rectal MRI synoptic reports. Recurrence-free survival was defined as the time between surgical resection and recurrence (local recurrence and/or metastatic disease) or death. Statistical analysis included Cox proportional hazards to determine associations between baseline rectal MRI/clinical characteristics and recurrence. Results: The median recurrence-free survival in the study sample was 6.4 years. Baseline rectal MRI characteristics associated with recurrence at univariable analysis were: age > 55 years (P = 0.044), low rectal tumor location (P = 0.04), craniocaudal length ≥ 5.0 cm (P = 0.007), anal canal involvement (P = 0.011), presence of suspicious total mesorectal excision (TME) lymph nodes > 0.5 cm (P = 0.03), mesorectal fascia involvement (P = 0.04), T3 stage (P = 0.024), T4 stage (P = 0.008), and M1 stage (P = 0.024). At multivariable analysis, only age > 55 years (P = 0.012) and the presence of suspicious TME lymph nodes > 0.5 cm (P = 0.049) remained associated with recurrence. Conclusion: Advanced age and the presence of suspicious TME adenopathy > 0.5 cm on baseline rectal MRI are associated with higher risk of recurrent disease in patients with resected rectal cancer. © 2025 Elsevier B.V.
Keywords:	adult; aged; cancer surgery; major clinical study; cancer recurrence; neoadjuvant therapy; cancer staging; nuclear magnetic resonance imaging; follow up; metastasis; cohort analysis; recurrence; retrospective study; prognostic factors; recurrent disease; rectum cancer; rectum tumor; diffusion weighted imaging; polypectomy; lymphadenopathy; rectal cancer; recurrence free survival; total mesorectal excision; tumor invasion; human; male; female; article; t2 weighted imaging; t1 weighted imaging; dynamic contrast enhanced imaging; external anal sphincter; internal anal sphincter
Journal Title:	European Journal of Radiology
Volume:	188
ISSN:	0720-048X
Publisher:	Elsevier B.V
Date Published:	2025-07-01
Start Page:	112152
Language:	English
DOI:	10.1016/j.ejrad.2025.112152
PROVIDER:	scopus
PMCID:	PMC12117528
PUBMED:	40319786
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-105003974556&doi=10.1016%2fj.ejrad.2025.112152&partnerID=40&md5=663f4eb6acd616112816693898337e26
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Iva Petkovska -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/225437