Dual targeting of EZH2 and EZH1 drives exit of leukemia stem cells from quiescence and potentiates chemotherapy in acute myeloid leukemia Research Letter
| Authors: | Akiyama, H.; Nishida, Y.; Chang, K. H.; Bedoy, A. D.; Muftuoglu, M.; Ma, W.; Basyal, M.; Hirschi, Z.; Honma, D.; Tsutsumi, S.; Wang, J.; Zhang, W.; Huang, X.; Rampal, R. K.; Oluwole, O. O.; Bixby, D. L.; Daver, N. G.; Andreeff, M. |
| Title: | Dual targeting of EZH2 and EZH1 drives exit of leukemia stem cells from quiescence and potentiates chemotherapy in acute myeloid leukemia |
| Keywords: | adult; cancer chemotherapy; cancer survival; controlled study; leukemia; cancer combination chemotherapy; nonhuman; cytarabine; letter; ki 67 antigen; cell proliferation; mouse; phenotype; cell cycle progression; apoptosis; animal experiment; animal model; in vitro study; tumor xenograft; protein p53; stem cell; flt3 ligand; oncogene c myc; azacitidine; cd33 antigen; leukemia remission; antileukemic activity; tumor microenvironment; transcription factor ezh2; oncogene n ras; acute myeloid leukemia; cell kinetics; refractory disease; cd123 antigen; human; rna sequencing; primary cell; venetoclax; ec50; adp ribosyl cyclase/cyclic adp ribose hydrolase 1; drug analysis; valemetostat |
| Journal Title: | Blood Cancer Journal |
| Volume: | 15 |
| ISSN: | 2044-5385 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2025-04-24 |
| Start Page: | 76 |
| Language: | English |
| DOI: | 10.1038/s41408-025-01266-0 |
| PUBMED: | 40274779 |
| PROVIDER: | scopus |
| PMCID: | PMC12022017 |
| DOI/URL: | |
| Notes: | Letter -- Source: Scopus |
