The International Association for the Study of Lung Cancer Lung Cancer staging project: Proposals for the revision of the clinical and pathologic staging of small cell lung cancer in the forthcoming eighth edition of the TNM classification for lung cancer Journal Article
| Authors: | Nicholson, A. G.; Chansky, K.; Crowley, J.; Beyruti, R.; Kubota, K.; Turrisi, A.; Eberhardt, W. E. E.; Van Meerbeeck, J.; Rami-Porta, R.; on behalf of the Staging and Prognostic Factors Committee, Advisory Boards, and Participating Institutions |
| Contributors: | Huang, J.; Rusch, V.; Travis, W.; Krug, L. |
| Article Title: | The International Association for the Study of Lung Cancer Lung Cancer staging project: Proposals for the revision of the clinical and pathologic staging of small cell lung cancer in the forthcoming eighth edition of the TNM classification for lung cancer |
| Abstract: | Introduction: Small cell lung cancer (SCLC) is commonly classified as either limited or extensive, but the Union for International Cancer Control TNM Classification of Malignant Tumours seventh edition (2009) recommended tumor, node, and metastasis (TNM) staging based on analysis of the International Association for the Study of Lung Cancer (IASLC) database. Methods: Survival analyses were performed for clinically and pathologically staged patients presenting with SCLC from 1999 through 2010. Prognosis was compared in relation to the TNM seventh edition staging to serve as validation and analyzed in relation to proposed changes to the T descriptors found in the eighth edition. Results: There were 5002 patients: 4848 patients with clinical and 582 with pathological stages. Among these, 428 had both. Survival differences were confirmed for T and N categories and maintained in relation to proposed revisions to T descriptors for seventh edition TNM categories and proposed changes in the eighth edition. There were also survival differences, notably at 12 months, in patients with brain-only single-site metastasis (SSM) compared to SSM at other sites, and SSM without a pleural effusion showed a better prognosis than other patients in the M1b category. Conclusion: We confirm the prognostic value of clinical and pathological TNM staging in patients with SCLC, and recommend continued usage for SCLC in relation to proposed changes to T, N, and M descriptors for NSCLC in the eighth edition. However, for M descriptors, it remains uncertain whether survival differences in patients with SSM in the brain simply reflect better treatment options rather than better survival based on anatomic extent of disease. © 2015 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; survival analysis; cancer surgery; major clinical study; overall survival; cancer radiotherapy; cancer staging; neoplasm staging; classification; lung neoplasms; lung cancer; pathology; lung tumor; brain metastasis; medical society; cancer classification; lung cancer staging; small cell lung cancer; small cell lung carcinoma; tnm classification; tumor invasion; cancer prognosis; humans; prognosis; human; priority journal; article |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 11 |
| Issue: | 3 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-03-01 |
| Start Page: | 300 |
| End Page: | 311 |
| Language: | English |
| DOI: | 10.1016/j.jtho.2015.10.008 |
| PUBMED: | 26723244 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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