Homologous recombination and replication fork protection: BRCA2 and more! Journal Article
| Authors: | Feng, W.; Jasin, M. |
| Article Title: | Homologous recombination and replication fork protection: BRCA2 and more! |
| Abstract: | BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances. © 2017 Feng and Jasin; Published by Cold Spring Harbor Laboratory Press. |
| Journal Title: | Cold Spring Harbor Symposia on Quantitative Biology |
| Volume: | 82 |
| ISSN: | 0091-7451 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2017-01-01 |
| Start Page: | 329 |
| End Page: | 338 |
| Language: | English |
| DOI: | 10.1101/sqb.2017.82.035006 |
| PUBMED: | 29686033 |
| PROVIDER: | scopus |
| PMCID: | PMC6333483 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Maria Jasin -- Source: Scopus |
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