Radiographic appearance of leptomeningeal disease in patients with EGFR-mutated non-small-cell lung carcinoma treated with tyrosine kinase inhibitors: A case series Journal Article

   


Authors: Sener, U.; Matin, N.; Yu, H.; Lin, A.; Yang, T. J.; Malani, R.
Article Title: Radiographic appearance of leptomeningeal disease in patients with EGFR-mutated non-small-cell lung carcinoma treated with tyrosine kinase inhibitors: A case series
Abstract: EGFR is frequently mutated in non-small-cell lung carcinomas (NSCLCs). Clinically available tyrosine kinase inhibitors (TKIs) are effective in treating EGFR-mutant NSCLC. In this case series, we present five patients with TKI-Treated EGFR-mutated NSCLC who developed leptomeningeal disease (LMD) lacking characteristic imaging findings. All five patients received TKIs prior to development of cytology-confirmed LMD. Clinical signs of LMD preceded radiographic evidence by 2-12 months. T790M, the most common resistance mutation to first-generation EGFR inhibitors, was identified in four cases. These cases illustrate that in patients with EGFR-mutant NSCLC, TKIs may effectively control LMD, creating a lag between onset of symptoms and observation of radiographic findings. © 2019 © 2019 Ugur Sener.
Keywords: gene mutation; exon; gene deletion; clinical feature; bevacizumab; erlotinib; cancer staging; nuclear magnetic resonance imaging; epidermal growth factor receptor; tyrosine kinase inhibitors; protein tyrosine kinase inhibitor; liver metastasis; lung metastasis; brain metastasis; targeted therapy; weakness; stereotactic radiosurgery; egfr; egfr gene; diplopia; liver biopsy; hearing impairment; clinical observation; meningeal metastasis; hydrocephalus; cerebrospinal fluid cytology; non small cell lung cancer; nsclc; whole brain radiotherapy; ventriculostomy; leptomeningeal disease; tumor imaging; brain radiography; human; priority journal; article; osimertinib; vestibulocochlear nerve disease
Journal Title: CNS Oncology
Volume: 8
Issue: 4
ISSN: 2045-0907
Publisher: Future Medicine  
Date Published: 2019-11-28
Start Page: CNS42
Language: English
DOI: 10.2217/cns-2019-0010
PUBMED: 31777268
PROVIDER: scopus
PMCID: PMC6912846
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139470053&doi=10.2217%2fcns-2019-0010&partnerID=40&md5=800f2f156691db0cac476b6c6b8d21e5
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Ugur Sener -- Source: Scopus
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MSK Authors
  1. Helena Alexandra Yu
    285 Yu
  2. Jonathan T Yang
    166 Yang
  3. Andrew Pei-En Lin
    49 Lin
  4. Rachna Malani
    38 Malani
  5. Ugur Sener
    16 Sener
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