Initial patient characteristics of Thoracic Surgical Oncology Group 102: A multicenter prospective registry of active surveillance in patients with multiple ground-glass opacities Conference Paper
| Authors: | Huang, J.; Tan, K. S.; Altorki, N.; Antonoff, M.; Blackmon, S.; Bueno, R.; Burt, B.; Demmy, T.; Evans, N.; Donahoe, L.; Harpole, D.; Jarrar, D.; Kozower, B.; Lanuti, M.; Liberman, M.; Lin, J.; Liou, D.; Liptay, M.; Luketich, J.; Pennathur, A.; Petersen, G.; Ripley, R.; Rochefort, M.; Seder, C. W.; Shrager, J.; Su, S.; Tong, B.; Shargall, Y.; Vaporciyan, A.; Waddell, T.; Weksler, B.; Wigle, D.; Yendamuri, S.; Jones, D. R. |
| Title: | Initial patient characteristics of Thoracic Surgical Oncology Group 102: A multicenter prospective registry of active surveillance in patients with multiple ground-glass opacities |
| Conference Title: | 104th Annual Meeting of the American Association for Thoracic Surgery (AATS) |
| Abstract: | Objective: Presentation with multiple ground-glass opacities (GGOs) is an increasingly common occurrence, and the optimal management of these lesions is unclear. Active surveillance has been increasingly adopted as a management strategy for other low-grade malignancies. We hypothesized that active surveillance could be a feasible and safe option for patients with multiple GGOs. Methods: Patients with ≥2 GGOs (ground-glass predominant, <50% solid, ≤3 cm) were enrolled in a multi-institutional registry and prospectively followed up on active surveillance with computed tomography scans every 6 to 12 months. Each GGO was catalogued and measured individually at each follow-up visit. Results: Target accrual was met, with 337 patients from 23 institutions. The mean age was 70 years (interquartile range, 65-77 years), and 74% were women. Most were former (70%) or current (9%) smokers, with a mean exposure of 30 pack-years (interquartile range [IQR], 15-44 pack-years). One half of the patients (51%) had a previous lung cancer, and the majority (86%) were already under surveillance at the time of study entry. The median number of GGOs per patient was 3 (IQR, 2-5), with a total of 1467 GGOs under surveillance. The median GGO size was 0.9 cm (IQR, 0.7-1.3 cm). Most GGOs were 0.5 to 1 cm in size. Conclusions: Active surveillance, rather than immediate intervention, was an acceptable option to patients, and accrual to this registry trial was feasible. Safety end points and long-term outcomes will be assessed in the planned 5-year follow-up in accordance with the protocol. © 2024 The American Association for Thoracic Surgery |
| Keywords: | lung cancer; active surveillance; ground-glass opacity |
| Journal Title | Journal of Thoracic and Cardiovascular Surgery |
| Volume: | 169 |
| Issue: | 4 |
| Conference Dates: | 2024 Apr 27-30 |
| Conference Location: | Toronto, Canada |
| ISBN: | 0022-5223 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2025-04-01 |
| Start Page: | 1100 |
| End Page: | 1107 |
| Language: | English |
| DOI: | 10.1016/j.jtcvs.2024.09.054 |
| PROVIDER: | scopus |
| PUBMED: | 39395785 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: James Huang -- Source: Scopus |
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