Better late than never: Delayed asparaginase during induction for acute lymphoblastic leukaemia in adults Editorial

  


Authors: Valtis, Y. K.; Luskin, M. R.
Title: Better late than never: Delayed asparaginase during induction for acute lymphoblastic leukaemia in adults
Abstract: Paediatric regimens which incorporate asparaginase have improved outcomes of adolescents and younger adults with acute lymphoblastic leukaemia but are limited by toxicity. This retrospective report by Tinajero and Xu suggests that delaying the timing of asparaginase administration during ALL induction may reduce risk of hepatotoxicity. Commentary on: Tinajero et al. Delaying pegaspargase during induction in adults with acute lymphoblastic leukaemia is associated with lower risk of high-grade hepatotoxicity without adversely impacting outcomes. Br J Haematol 2025; 206:868-875. © 2024 British Society for Haematology and John Wiley & Sons Ltd.
Keywords: adult; cancer chemotherapy; child; retrospective studies; overall survival; note; chemotherapy; liver toxicity; odds ratio; retrospective study; acute lymphoblastic leukemia; confidence interval; bilirubin; daunorubicin; asparaginase; precursor cell lymphoblastic leukemia-lymphoma; drug therapy; toxicity; polyethylene glycols; induction chemotherapy; macrogol derivative; all; asparaginase macrogol; humans; human; male; female; b cell acute lymphoblastic leukemia
Journal Title: British Journal of Haematology
Volume: 206
Issue: 3
ISSN: 0007-1048
Publisher: John Wiley & Sons  
Date Published: 2025-03-01
Start Page: 1016
End Page: 1017
Language: English
DOI: 10.1111/bjh.19928
PUBMED: 39582037
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85209993631&doi=10.1111%2fbjh.19928&partnerID=40&md5=0b045e89ff1689dfa709e4d0e322a636
Notes: Source: Scopus
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MSK Authors
  1. Ioannis Kalogirou Valtis
    24 Kalogirou Valtis
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