Tumor-infiltrating lymphocyte therapy for melanoma and other solid tumors: Looking back, yet moving forward Review
| Authors: | Shoushtari, A. N.; Powell, D. J. |
| Review Title: | Tumor-infiltrating lymphocyte therapy for melanoma and other solid tumors: Looking back, yet moving forward |
| Abstract: | Lifileucel, the first solid tumor adoptive tumor infiltrating lymphocyte (TIL) therapy product to receive regulatory approval in advanced melanoma, represents a critical achievement in the pursuit of improving outcomes using cellular therapies in patients with solid tumors. This review traces the development of adoptive TIL therapy from the initial human studies in melanoma, through recent advances in studies of other solid tumors, and previews ongoing and future areas for preclinical and clinical advances to improve upon this novel therapeutic strategy. © 2025 The American Society for Transplantation and Cellular Therapy |
| Keywords: | adult; clinical trial; review; nonhuman; side effect; solid tumor; tumor associated leukocyte; lymphocytes, tumor-infiltrating; animal; animals; melanoma; phase 2 clinical trial; pathology; transplantation; immunology; cell therapy; phase 1 clinical trial; drug therapy; therapy; adoptive immunotherapy; immunotherapy, adoptive; tumor-infiltrating lymphocytes; procedures; cellular therapy; humans; human; preclinical; til therapy; lifileucel |
| Journal Title: | Transplantation and Cellular Therapy |
| Volume: | 31 |
| Issue: | 3 Suppl. |
| ISSN: | 2666-6375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2025-03-01 |
| Start Page: | S581 |
| End Page: | S590 |
| Language: | English |
| DOI: | 10.1016/j.jtct.2024.11.017 |
| PUBMED: | 40089327 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Alexander N. Shoushtari -- Source: Scopus |
