A podcast discussion on the intracranial efficacy of antibody–Drug conjugates in patients with EGFR-mutated NSCLC with brain metastases Editorial
| Authors: | Johnson, M. L.; Lin, J. J.; Boire, A.; Khandekar, M. J.; Yu, H. A. |
| Title: | A podcast discussion on the intracranial efficacy of antibody–Drug conjugates in patients with EGFR-mutated NSCLC with brain metastases |
| Abstract: | The incidence of brain metastases is higher in patients with non-small cell lung cancer (NSCLC) than in patients with most other cancers, and the development of brain metastases is associated with poor prognosis. The objective of the podcast is to provide information about current and future treatments for brain metastases that develop in patients with EGFR-mutated NSCLC. The panel discusses surveillance and management of patients with brain metastases, different types of currently used treatments, and recent data on the intracranial efficacy of antibody–drug conjugates (ADCs). The panel also discusses current and future studies of ADCs in patients with EGFR-mutated NSCLC with brain metastases. This podcast discussion, among four oncologists (two thoracic oncologists, one radiation oncologist, and one neurologist/neuro-oncologist), is for healthcare professionals (HCPs) at community practices and research institutions. © The Author(s) 2024. |
| Keywords: | gene mutation; systemic therapy; note; chemotherapy; nuclear magnetic resonance imaging; progression free survival; quality of life; epidermal growth factor receptor; lung cancer; central nervous system; protein tyrosine kinase inhibitor; cerebrospinal fluid; brain metastasis; autopsy; drug therapy; disease control; non-small cell lung cancer; brain metastases; non small cell lung cancer; adc; cancer prognosis; neurologist; human; radiation oncologist; osimertinib; antibody drug conjugate; trastuzumab deruxtecan; podcast; antibody–drug conjugate; patritumab deruxtecan; egfr-mutated |
| Journal Title: | Oncology and Therapy |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 2366-1070 |
| Publisher: | Springer |
| Date Published: | 2025-03-01 |
| Start Page: | 17 |
| End Page: | 30 |
| Language: | English |
| DOI: | 10.1007/s40487-024-00315-1 |
| PROVIDER: | scopus |
| PMCID: | PMC11880489 |
| PUBMED: | 39695026 |
| DOI/URL: | |
| Notes: | Note -- Source: Scopus |
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