Combination of immune checkpoint blockade in metastatic colorectal cancers with microsatellite instability: A new standard of care? Editorial

  


Authors: Randrian, V.; Rousseau, B.
Title: Combination of immune checkpoint blockade in metastatic colorectal cancers with microsatellite instability: A new standard of care?
Abstract: Immunotherapy is highly efficient for the treatment of mismatch-repair-deficient metastatic colorectal cancer. Two recent articles1,2 challenge the current paradigm of anti-PD-1 monotherapy for the frontline treatment of metastatic mismatch-repair-deficient colorectal cancer, as the combination of an anti-PD-1 and anti-CTLA-4 showed improved response rate and progression-free survival compared to chemotherapy or anti PD-1. © 2025 Elsevier Inc.
Keywords: genetics; antineoplastic agent; metastasis; progression free survival; antineoplastic combined chemotherapy protocols; pathology; colorectal neoplasms; health care quality; immunology; colorectal tumor; microsatellite instability; neoplasm metastasis; drug therapy; cytotoxic t lymphocyte antigen 4; programmed death 1 receptor; progression-free survival; standard of care; immune checkpoint inhibitor; ctla-4 antigen; humans; human; programmed cell death 1 receptor; immune checkpoint inhibitors
Journal Title: Med
Volume: 6
Issue: 3
ISSN: 2666-6359
Publisher: Cell Press  
Date Published: 2025-03-14
Start Page: 100636
Language: English
DOI: 10.1016/j.medj.2025.100636
PUBMED: 40088883
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000654230&doi=10.1016%2fj.medj.2025.100636&partnerID=40&md5=a8bc5a5f608de6012ec9492640033cbf
Notes: Note -- Source: Scopus
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MSK Authors
  1. Benoit Rousseau
    51 Rousseau
  2. Violaine Randrian
    1 Randrian
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