Multiple myeloma Book Section

  


Authors: Lu, S. X.; Rustad, E. H.; Usmani, S. Z.; Landgren, C. O.
Editors: Hoffman, R.; Benz, E. J. Jr; Silberstein, L. E.; Heslop, H. E.; Weitz, J. I.; Salama, M. E.; Abutalib, S. A.
Article/Chapter Title: Multiple myeloma
Abstract: Clonal plasma cell (PC) neoplasms are comprised of a number of interrelated and partially overlapping entities, ranging from benign to fully malignant, which are variously defined and categorized by burden of disease, presence of organ injury, anatomic location, and in some cases, unique constellations of signs, symptoms, and pathologic findings. This chapter highlights continued advances in both knowledge regarding the underlying pathophysiology of PC neoplasms, and their therapy, with a focus on multiple myeloma (MM) as the prototypical malignant PC disorder. In this context we emphasize minimal residual disease (MRD) testing for risk stratification, disease management, and decision making, and also highlight novel therapies with mechanisms-of-action beyond existing proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. © 2023 by Elsevier Inc. All rights reserved.
Keywords: multiple myeloma; plasma cell leukemia; solitary plasmacytoma; plasma cell dyscrasias; symptomatic myeloma
Book Title: Hematology: Basic Principles and Practice. 8th ed
ISBN: 978-032373388-5
Publisher: Elsevier Inc.  
Publication Place: Philadelphia, PA
Date Published: 2023-01-01
Start Page: 1506
End Page: 1538
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000570198&doi=10.1016%2fB978-0-323-73388-5.00091-2&partnerID=40&md5=6963c84130d8192bb1e7247ab6b9835a
Notes: Book chapter: 91 -- Source: Scopus