| Abstract: |
IntroductionFollicular lymphoma (FL) has a heterogeneous prognosis. Progression within 24 months of starting front-line therapy (POD24) is prognostic of overall survival (OS). Despite its prognostic value in early lines, the role of POD24 in relapsed/refractory (R/R) patients initiating later lines of therapy (LoTs) is unknown.MethodsWe analyzed the SCHOLAR-5 real-world cohort to investigate whether POD24 is prognostic in patients with R/R FL initiating >= 3rd LoT.ResultsAmong the 128 SCHOLAR-5 patients, 34 patients experienced POD24. POD24 patients received their >= 3 LoT after a shorter time compared with non-POD24 patients (median 42.0 months [range: 8.8-17.8] vs. 109.9 months [range: 29.6-310.2]). Using a time-dependent multivariate Cox model, POD24 was predictive of shorter OS from initiation of >= 3rd LoT with a hazard ratio (HR) of 2.44 (95% confidence interval [CI]: 1.20-4.96). For progression-free survival, using a multivariate repeated-measures Cox model, the effect was similar but not statistically significant (HR: 1.45; 95% CI: 0.94-2.11).ConclusionThis study demonstrates that among patients with R/R FL initiating a >= 3rd LoT, POD24 patients reach these LoTs sooner after diagnosis and POD24 remains prognostic of subsequent OS. This suggests that POD24 status can inform clinical decision making in this population. |
