A woman with mycosis fungoides, vitiligo, and a new hand nodule Journal Article
| Authors: | Feghali, J.; Lavin, L.; Ng, S.; Linos, K.; Geller, S. |
| Article Title: | A woman with mycosis fungoides, vitiligo, and a new hand nodule |
| Abstract: | A 70-year-old African American female with a history of stage IV mycosis fungoides in remission presented with a gradually enlarging, red, ulcerated nodule on her right dorsal hand. The lesion was biopsied, and it showed intraepidermal proliferation with cytologic atypia and increased vasculature in the papillary dermis. Immunohistochemical staining indicated a yes-associated protein 1 (YAP1) rearrangement, confirmed by RNA sequencing, revealing a YAP1::MAML2 (mastermind-like transcriptional coactivator 2) fusion. The lesion was diagnosed as an eccrine porocarcinoma (EPC). The occurrence of EPCs following radiotherapy or trauma has been documented. This case highlights the importance of considering EPCs in patients with extensive skin treatments and immunosuppression history. © 2024 the International Society of Dermatology. |
| Keywords: | immunohistochemistry; clinical article; human tissue; aged; unclassified drug; histopathology; case report; squamous cell carcinoma; diarrhea; cancer radiotherapy; follow up; cell proliferation; skin biopsy; skin defect; nuclear protein; carboxy terminal sequence; skin cancer; transcription factor; histology; abdominal pain; chill; fever; cutaneous t cell lymphoma; gene rearrangement; amino terminal sequence; staining; gene fusion; remission; eosin; hematoxylin; physical examination; immunosuppressive treatment; mycosis fungoides; skin bleeding; night sweat; hand disease; vitiligo; eccrine porocarcinoma; body weight loss; lymphomatoid papulosis; dermatological procedure; human; female; article; rna sequencing; papillary dermis; eccrine; hand injury; yes associated protein 1; yap signaling protein; skin of color (soc); mastermind like transcriptional coactivator 2; hand nodule; hand ulcer |
| Journal Title: | International Journal of Dermatology |
| Volume: | 64 |
| Issue: | 3 |
| ISSN: | 0011-9059 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2025-03-01 |
| Start Page: | 513 |
| End Page: | 516 |
| Language: | English |
| DOI: | 10.1111/ijd.17552 |
| PUBMED: | 39450936 |
| PROVIDER: | scopus |
| PMCID: | PMC11842194 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Shamir Geller -- Source: Scopus |
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