FAP-targeted SPECT/CT and PET/CT imaging for breast cancer patients Review
| Authors: | McGale, J.; Khurana, S.; Howell, H.; Nakhla, A.; Roa, T.; Doshi, P.; Shirini, D.; Huang, A.; Duong, P.; Backhaus, P.; Liao, M.; Kaur, H.; Fontani, A. M.; Hung, I.; Pandit-Taskar, N.; Haberkorn, U.; Gulati, A.; Naim, A.; Sinigaglia, M.; Bebawy, M.; Girard, A.; Seban, R. D.; Dercle, L. |
| Review Title: | FAP-targeted SPECT/CT and PET/CT imaging for breast cancer patients |
| Abstract: | Breast cancer presents a significant global health challenge, necessitating continued innovation in diagnostic and therapeutic approaches. Recent advances have led to the identification of cancer-associated fibroblasts, which are highly prevalent in breast cancers and express fibroblast activation proteins (FAPs), as critical targets. FAP-specific radiotracers, when used with PET/CT and SPECT/CT, have significant potential for improving early breast cancer detection, staging, treatment response monitoring, and therapeutic intervention. This review provides insight into FAP-targeted molecular imaging, exploring advanced techniques for protein status assessment, development of early-phase targeted therapies, and other emerging applications. The advent of FAP-targeted imaging stands to significantly enhance personalized oncologic care, leading to improved breast cancer management and overall patient outcomes. © Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | treatment response; cancer patient; cancer diagnosis; metabolism; breast cancer; membrane proteins; diagnostic imaging; breast neoplasms; prediction; seprase; serine proteinase; serine endopeptidases; artificial intelligence; breast tumor; membrane protein; fluorodeoxyglucose f 18; fibroblast; proteinase; tracer; radioisotope; pet; genetic heterogeneity; endopeptidases; spect; tumor microenvironment; fibroblast activation protein; cancer associated fibroblast; clinical outcome; gelatinases; gelatinase; radionuclide therapy; nuclear imaging; humans; human; female; article; radiomics; positron emission tomography-computed tomography; positron emission tomography computed tomography; single photon emission computed tomography-computed tomography; single photon emission computed tomography computed tomography; cancer associated fibroblasts |
| Journal Title: | Clinical Nuclear Medicine |
| Volume: | 50 |
| Issue: | 3 |
| ISSN: | 0363-9762 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2025-03-01 |
| Start Page: | e138 |
| End Page: | e145 |
| Language: | English |
| DOI: | 10.1097/rlu.0000000000005617 |
| PUBMED: | 39780367 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
