A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis Review
| Authors: | Haque, T.; Shastri, A.; Desai, P.; Xie, Z.; Hammond, D.; King, Z.; Kishtagari, A.; Madanat, Y. F.; Abaza, Y.; Silver, A. J.; Singh, A.; Borate, U. M.; Heimlich, J. B.; Slosky, D. A.; Bolton, K. L.; Patnaik, M. S.; Bick, A. G.; Verma, A. K.; Jaiswal, S.; Steensma, D. P.; Savona, M. R. |
| Review Title: | A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis |
| Abstract: | The age-associated mutational state of clonal haematopoiesis (CH) is linked to multiple adverse health outcomes. As higher risk CH can lead to progressive neoplastic or vascular disease, there is interest in developing clinical trials to mitigate risk associated with CH. Given the high prevalence of CH, data from clinical trials could have broad public health implications for screening and therapy. Thoughtful consideration is needed to design trials that are both clinically relevant and avoid overmedicalization. Here, we summarize clinical studies of CH to date and provide suggestions and guidance on how to approach designing CH-focused therapeutic clinical trials. These recommendations are derived from discussions among clinical researchers and scientists emanating from the Inaugural Meeting on Somatic Mutations and Predisease in October 2021. © 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. |
| Keywords: | somatic mutation; review; prevalence; drug development; drug therapy; cytopenia; therapy; clinical trials; vascular disease; clonal hematopoiesis; human; clonal cytopenias; overmedicalization |
| Journal Title: | British Journal of Haematology |
| Volume: | 206 |
| Issue: | 2 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2025-02-01 |
| Start Page: | 416 |
| End Page: | 427 |
| Language: | English |
| DOI: | 10.1111/bjh.19925 |
| PUBMED: | 39653653 |
| PROVIDER: | scopus |
| PMCID: | PMC11829135 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
