Pre-injury frailty and clinical care trajectory of older adults with trauma injuries: A retrospective cohort analysis of a large level I US trauma center Journal Article


Authors: Adeyemi, O.; Grudzen, C.; Dimaggio, C.; Wittman, I.; Velez-Rosborough, A.; Arcila-Mesa, M.; Cuthel, A.; Poracky, H.; Meyman, P.; Chodosh, J.
Article Title: Pre-injury frailty and clinical care trajectory of older adults with trauma injuries: A retrospective cohort analysis of a large level I US trauma center
Abstract: Background Pre-injury frailty among older adults with trauma injuries is a predictor of increased morbidity and mortality. Objectives We sought to determine the relationship between frailty status and the care trajectories of older adult patients who underwent frailty screening in the emergency department (ED). Methods Using a retrospective cohort design, we pooled trauma data from a single institutional trauma database from August 2020 to June 2023. We limited the data to adults 65 years and older, who had trauma injuries and frailty screening at ED presentation (N = 2,862). The predictor variable was frailty status, measured as either robust (score 0), pre-frail (score 1–2), or frail (score 3–5) using the FRAIL index. The outcome variables were measures of clinical care trajectory: trauma team activation, inpatient admission, ED discharge, length of hospital stay, in-hospital death, home discharge, and discharge to rehabilitation. We controlled for age, sex, race/ethnicity, health insurance type, body mass index, Charlson Comorbidity Index, injury type and severity, and Glasgow Coma Scale score. We performed multivariable logistic and quantile regressions to measure the influence of frailty on post-trauma care trajectories. Results The mean (SD) age of the study population was 80 (8.9) years, and the population was predominantly female (64%) and non-Hispanic White (60%). Compared to those classified as robust, those categorized as frail had 2.5 (95% CI: 1.86–3.23), 3.1 (95% CI: 2.28–4.12), and 0.3 (95% CI: 0.23–0.42) times the adjusted odds of trauma team activation, inpatient admission, and ED discharge, respectively. Also, those classified as frail had significantly longer lengths of hospital stay as well as 3.7 (1.07–12.62), 0.4 (0.28–0.47), and 2.2 (95% CI: 1.71–2.91) times the odds of in-hospital death, home discharge, and discharge to rehabilitation, respectively. Conclusion Pre-injury frailty is a predictor of clinical care trajectories for older adults with trauma injuries. © 2025 Adeyemi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: aged; aged, 80 and over; retrospective studies; fatigue; mortality; united states; neurosurgery; morbidity; cohort analysis; retrospective study; health care; health insurance; emergency ward; length of stay; emergency service, hospital; hospitalization; body mass; disease severity; multivariate logistic regression analysis; hospital admission; hospital discharge; patient discharge; epidemiology; frail elderly; therapy; orthopedics; injury; emergency health service; human experiment; anesthesia; nursing home; hospital mortality; in-hospital mortality; wounds and injuries; body weight loss; frailty; charlson comorbidity index; very elderly; humans; human; male; female; article; glasgow coma scale; injury scale; hospital emergency service; trauma centers; clinical care trajectory; preinjury frailty
Journal Title: PLoS ONE
Volume: 20
Issue: 2
ISSN: 1932-6203
Publisher: Public Library of Science  
Date Published: 2025-02-05
Start Page: e0317305
Language: English
DOI: 10.1371/journal.pone.0317305
PUBMED: 39908306
PROVIDER: scopus
PMCID: PMC11798440
DOI/URL:
Notes: Source: Scopus
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  1. Corita Reilley Grudzen
    31 Grudzen