Frank invasion in tall cell carcinoma with reversed polarity of the breast: Report of two cases Journal Article
| Authors: | Han, R.; Pareja, F.; Ross, D. S.; Grabenstetter, A.; Wen, H. Y.; Brogi, E. |
| Article Title: | Frank invasion in tall cell carcinoma with reversed polarity of the breast: Report of two cases |
| Abstract: | Tall cell carcinoma with reversed polarity (TCCRP) is a rare neoplasm of the breast composed of columnar tumor cells arranged in solid and solid-papillary nests with evidence of apical nuclear polarity. No frank invasion is evident despite the lack of a myoepithelial cell layer throughout the tumor. TCCRP has a triple-negative or hormone receptor-low immunophenotype. Recurrent IDH2 R172 hotspot mutation coexisting with genetic alterations in the PI3K pathway characterizes this tumor. Here, we report on 2 postmenopausal patients with TCCRP with frank stromal invasion. IDH2 R172 mutations were detected in both tumors by immunohistochemistry. Targeted sequencing of case 2 demonstrated the presence of IDH2 R172T and RTEL1 E839K mutations. Both patients underwent breast conservation surgery, radiation therapy, and adjuvant endocrine therapy with anastrozole and demonstrated no evidence of disease at 65 and 25 months, respectively. This study suggests that TCCRP may give rise to frank invasive carcinoma, the prognostic significance of which is yet unknown. © 2025 |
| Keywords: | immunohistochemistry; adult; clinical article; controlled study; human tissue; aged; middle aged; histopathology; case report; cancer radiotherapy; nuclear magnetic resonance imaging; breast cancer; transcription factor gata 3; echomammography; cancer hormone therapy; mammography; protein s 100; protein p63; anastrozole; protein msh6; cell invasion; mismatch repair protein pms2; calretinin; cytokeratin 8; keratin; triple-negative breast cancer; wide excision; breast-conserving surgery; lymphocytosis; cytokeratin 17; lymph vessel metastasis; isocitrate dehydrogenase 2; human; female; article; positron emission tomography-computed tomography; mutl protein homolog 1; dna mismatch repair protein msh2; breast radiotherapy; tall cell carcinoma with reversed polarity; idh2 mutation; invasive ductal breast carcinoma |
| Journal Title: | Modern Pathology |
| Volume: | 38 |
| Issue: | 5 |
| ISSN: | 0893-3952 |
| Publisher: | Nature Research |
| Date Published: | 2025-05-01 |
| Start Page: | 100714 |
| Language: | English |
| DOI: | 10.1016/j.modpat.2025.100714 |
| PUBMED: | 39828059 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged on PDF -- MSK corresponding author is Edi Brogi -- Source: Scopus |
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