Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns Journal Article
| Authors: | Puvvula, J.; Song, L. C.; Zalewska, K. J.; Alexander, A.; Manz, K. E.; Braun, J. M.; Pennell, K. D.; DeFranco, E. A.; Ho, S. M.; Leung, Y. K.; Huang, S.; Vuong, A. M.; Kim, S. S.; Percy, Z.; Bhashyam, P.; Lee, R.; Jones, D. P.; Tran, V.; Kim, D. V.; Calafat, A. M.; Botelho, J. C.; Chen, A. |
| Article Title: | Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns |
| Abstract: | Background: Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery. Methods: This study included 75 pregnant individuals who delivered at the University of Cincinnati Hospital from 2014 to 2017. We measured maternal urinary biomarkers of paraben/phenol (12), phthalate (13), and phthalate replacements (4) from the samples collected during the delivery visit. Global serum metabolome profiles were analyzed from maternal blood (n = 72) and newborn (n = 63) cord blood samples collected at delivery. Fifteen of the 29 urinary biomarkers were excluded due to low detection frequency or potential exposures during hospital stay. We assessed metabolome-wide associations between 14 maternal urinary biomarkers and maternal/newborn metabolome profiles. Additionally, performed enrichment analysis to identify potential alterations in metabolic pathways. Results: We observed metabolome-wide associations between maternal urinary concentrations of phthalate metabolites (mono-isobutyl phthalate), phthalate replacements (mono-2-ethyl-5-carboxypentyl terephthalate, mono-2-ethyl-5-hydroxyhexyl terephthalate) and phenols (bisphenol-A, bisphenol-S) and maternal serum metabolome, using q-value < 0.2 as a threshold. Additionally, associations of phthalate metabolites (mono-n-butyl phthalate, monobenzyl phthalate) and phenols (2,5-dichlorophenol, BPA) with the newborn metabolome were noted. Enrichment analyses revealed associations (p-gamma < 0.05) with amino acid, carbohydrate, lipid, glycan, vitamin, and other cofactor metabolism pathways. Conclusion: Maternal paraben, phenol, phthalate, and phthalate replacement biomarker concentrations at delivery were associated with maternal and newborn serum global metabolome. © The Author(s) 2025. |
| Keywords: | adult; young adult; unclassified drug; major clinical study; follow up; mass spectrometry; biomarkers; biological marker; phenotype; metabolism; hospitalization; blood; body mass; chemistry; fetal blood; fetus blood; algorithm; infant, newborn; blood sampling; gestational age; newborn; pregnancy; urine; fetus; metabolite; carbohydrate; pregnancy outcome; vitamin; endocrine system; adverse event; metabolomics; maternal exposure; oxybenzone; limit of detection; pregnant woman; glycan; liquid chromatography-mass spectrometry; procedures; 4 hydroxybenzoic acid ester; phenol; triclosan; phthalic acid; phthalic acids; endocrine disruptors; humans; human; female; article; ultra performance liquid chromatography; monobenzyl phthalate; phthalate; endocrine disruptor; metabolome; untargeted metabolomics; 2,5 dichlorophenol; bisphenol a; bisphenol f; bisphenol s; butyl paraben; cyclohexane-1,2-dicarboxylic acid; ethyl paraben; methyl paraben; mono 3 carboxypropyl phthalate; mono carboxyisononyl phthalate; mono carboxyisooctyl phthalate; mono-2-ethyl-5-carboxypentyl phthalate; mono-2-ethyl-5-carboxypentyl terephthalate; mono-2-ethyl-5-hydroxyhexyl phthalate; mono-2-ethyl-5-hydroxyhexyl terephthalate; mono-2-ethyl-5-oxohexyl phthalate; mono-2-ethylhexyl phthalate; mono-isononyl phthalate; mono-n-butyl phthalate; monocarboxyisooctyl ester; monohydroxyisononyl ester; monoisobutyl phthalate; monooxononyl phthalate; propyl paraben; triclocarban; phthalic acid derivative; endocrine related metabolic pathway; kidney concentrating capacity |
| Journal Title: | Metabolomics |
| Volume: | 21 |
| Issue: | 1 |
| ISSN: | 1573-3882 |
| Publisher: | Springer |
| Date Published: | 2025-02-01 |
| Start Page: | 20 |
| Language: | English |
| DOI: | 10.1007/s11306-024-02219-7 |
| PUBMED: | 39863779 |
| PROVIDER: | scopus |
| PMCID: | PMC11762426 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
