Management of immune checkpoint inhibitor-associated toxicities in older adults with cancer: Recommendations from the International Society of Geriatric Oncology (SIOG) Review

  


Authors: Eochagain, C. M.; Neuendorff, N. R.; Gente, K.; Leipe, J.; Verhaert, M.; Sam, C.; de Glas, N.; Kadambi, S.; Canin, B.; Gomes, F.; Decoster, L.; Korc-Grodzicki, B.; Rostoft, S.; Battisti, N. M. L.; Wildiers, H.
Review Title: Management of immune checkpoint inhibitor-associated toxicities in older adults with cancer: Recommendations from the International Society of Geriatric Oncology (SIOG)
Abstract: Immune checkpoint inhibitors (ICIs) have substantially advanced the treatment landscape for a wide variety of malignancies. Older adults represent a large and rapidly growing demographic, among whom ICIs are widely prescribed. Management of ICI-associated toxicity among older adults, particularly in the presence of frailty and comorbidity, poses unique challenges. In this Policy Review, developed by the International Society of Geriatric Oncology (SIOG), we offer an evidence-based framework for health-care providers, caregivers, and policy makers for treating older adults with ICIs, focusing on unique considerations for this population that are not adequately addressed by existing guidelines, and expanding them to encompass geriatric oncology principles. © 2025 Elsevier Ltd
Keywords: adult; aged; aged, 80 and over; review; side effect; neoplasm; neoplasms; evidence based practice; practice guideline; age factors; oncology; age; comorbidity; medical oncology; health care personnel; caregiver; clinical practice guideline; drug therapy; toxicity; therapy; geriatric assessment; geriatrics; frailty; immune checkpoint inhibitor; very elderly; humans; human; immune checkpoint inhibitors; malignant neoplasm; special situation for pharmacovigilance
Journal Title: Lancet Oncology
Volume: 26
Issue: 2
ISSN: 1470-2045
Publisher: Elsevier Science, Inc.  
Date Published: 2025-02-01
Start Page: e90
End Page: e102
Language: English
DOI: 10.1016/s1470-2045(24)00404-2
PUBMED: 39914430
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216690738&doi=10.1016%2fS1470-2045%2824%2900404-2&partnerID=40&md5=e95a226d3a9bbb7fb743105b85daa042
Notes: Review -- Source: Scopus
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  1. Beatriz Korc-Grodzicki
    129 Korc-Grodzicki
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