Feasibility of utilizing a brief neurocognitive battery in 3-year-old patients during treatment for acute lymphoblastic leukemia Journal Article
| Authors: | Ramjan, S.; Cole, P. D.; Blair-Thies, M.; Silverman, L. B.; Fredrickson, A.; Schembri, A.; Welch, J. J. G.; Kahn, J.; Kelly, K. M.; Tran, T. H.; Michon, B.; Gennarini, L.; Sands, S. A. |
| Article Title: | Feasibility of utilizing a brief neurocognitive battery in 3-year-old patients during treatment for acute lymphoblastic leukemia |
| Abstract: | Treatment of acute lymphoblastic leukemia (ALL) is associated with neurocognitive deficits in young children. While computerized measures have been utilized in pediatric oncology research, they exclude patients below the age of 4 years. Patients enrolled on “Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents” were offered participation in an optional neurocognitive study. Three-year old patients did not differ from 4-year-old patients in their ability to perform or complete the tests. Including patients diagnosed at age 3 will serve to improve our understanding of at-risk patients and their neurocognitive trajectory both during and after treatment. © 2024 Wiley Periodicals LLC. |
| Keywords: | cancer chemotherapy; child; preschool child; major clinical study; methotrexate; drug megadose; antineoplastic agent; cohort analysis; acute lymphoblastic leukemia; cognition; neuropsychological assessment; attention; task performance; induction chemotherapy; psychomotor activity; human; male; female; article; cogstate; computerized battery; brief cogstate battery |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 72 |
| Issue: | 3 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2025-03-01 |
| Start Page: | e31469 |
| Language: | English |
| DOI: | 10.1002/pbc.31469 |
| PUBMED: | 39654084 |
| PROVIDER: | scopus |
| PMCID: | PMC11759646 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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